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Proteomic profiling platforms head to head: Leveraging genetics and clinical traits to compare aptamer- and antibody-based methods.
Katz DH, Robbins JM, Deng S, Tahir UA, Bick AG, Pampana A, Yu Z, Ngo D, Benson MD, Chen ZZ, Cruz DE, Shen D, Gao Y, Bouchard C, Sarzynski MA, Correa A, Natarajan P, Wilson JG, Gerszten RE. Katz DH, et al. Among authors: gerszten re. Sci Adv. 2022 Aug 19;8(33):eabm5164. doi: 10.1126/sciadv.abm5164. Epub 2022 Aug 19. Sci Adv. 2022. PMID: 35984888 Free PMC article.
A pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease.
Addona TA, Shi X, Keshishian H, Mani DR, Burgess M, Gillette MA, Clauser KR, Shen D, Lewis GD, Farrell LA, Fifer MA, Sabatine MS, Gerszten RE, Carr SA. Addona TA, et al. Among authors: gerszten re. Nat Biotechnol. 2011 Jun 19;29(7):635-43. doi: 10.1038/nbt.1899. Nat Biotechnol. 2011. PMID: 21685905 Free PMC article.
Metabolic Profiling of Right Ventricular-Pulmonary Vascular Function Reveals Circulating Biomarkers of Pulmonary Hypertension.
Lewis GD, Ngo D, Hemnes AR, Farrell L, Domos C, Pappagianopoulos PP, Dhakal BP, Souza A, Shi X, Pugh ME, Beloiartsev A, Sinha S, Clish CB, Gerszten RE. Lewis GD, et al. Among authors: gerszten re. J Am Coll Cardiol. 2016 Jan 19;67(2):174-189. doi: 10.1016/j.jacc.2015.10.072. J Am Coll Cardiol. 2016. PMID: 26791065 Free PMC article.
Aptamer-Based Proteomic Profiling Reveals Novel Candidate Biomarkers and Pathways in Cardiovascular Disease.
Ngo D, Sinha S, Shen D, Kuhn EW, Keyes MJ, Shi X, Benson MD, O'Sullivan JF, Keshishian H, Farrell LA, Fifer MA, Vasan RS, Sabatine MS, Larson MG, Carr SA, Wang TJ, Gerszten RE. Ngo D, et al. Among authors: gerszten re. Circulation. 2016 Jul 26;134(4):270-85. doi: 10.1161/CIRCULATIONAHA.116.021803. Circulation. 2016. PMID: 27444932 Free PMC article.
Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes.
O'Sullivan JF, Morningstar JE, Yang Q, Zheng B, Gao Y, Jeanfavre S, Scott J, Fernandez C, Zheng H, O'Connor S, Cohen P, Vasan RS, Long MT, Wilson JG, Melander O, Wang TJ, Fox C, Peterson RT, Clish CB, Corey KE, Gerszten RE. O'Sullivan JF, et al. Among authors: gerszten re. J Clin Invest. 2017 Dec 1;127(12):4394-4402. doi: 10.1172/JCI95995. Epub 2017 Oct 30. J Clin Invest. 2017. PMID: 29083323 Free PMC article. Clinical Trial.
Genetic Architecture of the Cardiovascular Risk Proteome.
Benson MD, Yang Q, Ngo D, Zhu Y, Shen D, Farrell LA, Sinha S, Keyes MJ, Vasan RS, Larson MG, Smith JG, Wang TJ, Gerszten RE. Benson MD, et al. Among authors: gerszten re. Circulation. 2018 Mar 13;137(11):1158-1172. doi: 10.1161/CIRCULATIONAHA.117.029536. Epub 2017 Dec 19. Circulation. 2018. PMID: 29258991 Free PMC article.
318 results