Willard FS - Search Results

1

LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept.

Coskun T, Urva S, Roell WC, Qu H, Loghin C, Moyers JS, O'Farrell LS, Briere DA, Sloop KW, Thomas MK, Pirro V, Wainscott DB, Willard FS, Abernathy M, Morford L, Du Y, Benson C, Gimeno RE, Haupt A, Milicevic Z. Coskun T, et al. Among authors: willard fs. Cell Metab. 2022 Sep 6;34(9):1234-1247.e9. doi: 10.1016/j.cmet.2022.07.013. Epub 2022 Aug 18. Cell Metab. 2022. PMID: 35985340 Free article.

2

Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets.

Sloop KW, Willard FS, Brenner MB, Ficorilli J, Valasek K, Showalter AD, Farb TB, Cao JX, Cox AL, Michael MD, Gutierrez Sanfeliciano SM, Tebbe MJ, Coghlan MJ. Sloop KW, et al. Among authors: willard fs. Diabetes. 2010 Dec;59(12):3099-107. doi: 10.2337/db10-0689. Epub 2010 Sep 7. Diabetes. 2010. PMID: 20823098 Free PMC article.

3

Small molecule drug discovery at the glucagon-like peptide-1 receptor.

Willard FS, Bueno AB, Sloop KW. Willard FS, et al. Exp Diabetes Res. 2012;2012:709893. doi: 10.1155/2012/709893. Epub 2012 Feb 23. Exp Diabetes Res. 2012. PMID: 22611375 Free PMC article. Review.

4

Physiology and emerging biochemistry of the glucagon-like peptide-1 receptor.

Willard FS, Sloop KW. Willard FS, et al. Exp Diabetes Res. 2012;2012:470851. doi: 10.1155/2012/470851. Epub 2012 May 14. Exp Diabetes Res. 2012. PMID: 22666230 Free PMC article. Review.

5

Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin.

Willard FS, Wootten D, Showalter AD, Savage EE, Ficorilli J, Farb TB, Bokvist K, Alsina-Fernandez J, Furness SG, Christopoulos A, Sexton PM, Sloop KW. Willard FS, et al. Mol Pharmacol. 2012 Dec;82(6):1066-73. doi: 10.1124/mol.112.080432. Epub 2012 Aug 28. Mol Pharmacol. 2012. PMID: 22930710

6

Differential activation and modulation of the glucagon-like peptide-1 receptor by small molecule ligands.

Wootten D, Savage EE, Willard FS, Bueno AB, Sloop KW, Christopoulos A, Sexton PM. Wootten D, et al. Among authors: willard fs. Mol Pharmacol. 2013 Apr;83(4):822-34. doi: 10.1124/mol.112.084525. Epub 2013 Jan 24. Mol Pharmacol. 2013. PMID: 23348499

7

Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells.

Zhang M, Robitaille M, Showalter AD, Huang X, Liu Y, Bhattacharjee A, Willard FS, Han J, Froese S, Wei L, Gaisano HY, Angers S, Sloop KW, Dai FF, Wheeler MB. Zhang M, et al. Among authors: willard fs. Mol Cell Proteomics. 2014 Nov;13(11):3049-62. doi: 10.1074/mcp.M114.040196. Epub 2014 Jul 20. Mol Cell Proteomics. 2014. PMID: 25044020 Free PMC article.

8

Glucagon-like peptide-1 receptor ligand interactions: structural cross talk between ligands and the extracellular domain.

West GM, Willard FS, Sloop KW, Showalter AD, Pascal BD, Griffin PR. West GM, et al. Among authors: willard fs. PLoS One. 2014 Sep 2;9(9):e105683. doi: 10.1371/journal.pone.0105683. eCollection 2014. PLoS One. 2014. PMID: 25180755 Free PMC article.

9

Positive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse Electrophiles.

Bueno AB, Showalter AD, Wainscott DB, Stutsman C, Marín A, Ficorilli J, Cabrera O, Willard FS, Sloop KW. Bueno AB, et al. Among authors: willard fs. J Biol Chem. 2016 May 13;291(20):10700-15. doi: 10.1074/jbc.M115.696039. Epub 2016 Mar 14. J Biol Chem. 2016. PMID: 26975372 Free PMC article.

10

The current state of GPCR-based drug discovery to treat metabolic disease.

Sloop KW, Emmerson PJ, Statnick MA, Willard FS. Sloop KW, et al. Among authors: willard fs. Br J Pharmacol. 2018 Nov;175(21):4060-4071. doi: 10.1111/bph.14157. Epub 2018 Mar 25. Br J Pharmacol. 2018. PMID: 29394497 Free PMC article. Review.

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