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Page 1
ADAM17 cleaves the insulin receptor ectodomain on endothelial cells and causes vascular insulin resistance.
Ghiarone T, Castorena-Gonzalez JA, Foote CA, Ramirez-Perez FI, Ferreira-Santos L, Cabral-Amador FJ, de la Torre R, Ganga RR, Wheeler AA, Manrique-Acevedo C, Padilla J, Martinez-Lemus LA. Ghiarone T, et al. Am J Physiol Heart Circ Physiol. 2022 Oct 1;323(4):H688-H701. doi: 10.1152/ajpheart.00039.2022. Epub 2022 Aug 26. Am J Physiol Heart Circ Physiol. 2022. PMID: 36018759 Free PMC article.
Persistent insulin signaling coupled with restricted PI3K activation causes insulin-induced vasoconstriction.
Olver TD, Grunewald ZI, Ghiarone T, Restaino RM, Sales ARK, Park LK, Thorne PK, Ganga RR, Emter CA, Lemon PWR, Shoemaker JK, Manrique-Acevedo C, Martinez-Lemus LA, Padilla J. Olver TD, et al. Among authors: ghiarone t. Am J Physiol Heart Circ Physiol. 2019 Nov 1;317(5):H1166-H1172. doi: 10.1152/ajpheart.00464.2019. Epub 2019 Oct 11. Am J Physiol Heart Circ Physiol. 2019. PMID: 31603345 Free PMC article.
Sexual Dimorphism in Obesity-Associated Endothelial ENaC Activity and Stiffening in Mice.
Padilla J, Woodford ML, Lastra-Gonzalez G, Martinez-Diaz V, Fujie S, Yang Y, Lising AMC, Ramirez-Perez FI, Aroor AR, Morales-Quinones M, Ghiarone T, Whaley-Connell A, Martinez-Lemus LA, Hill MA, Manrique-Acevedo C. Padilla J, et al. Among authors: ghiarone t. Endocrinology. 2019 Dec 1;160(12):2918-2928. doi: 10.1210/en.2019-00483. Endocrinology. 2019. PMID: 31617909 Free PMC article.
Chronic Elevation of Endothelin-1 Alone May Not Be Sufficient to Impair Endothelium-Dependent Relaxation.
Grunewald ZI, Jurrissen TJ, Woodford ML, Ramirez-Perez FI, Park LK, Pettit-Mee R, Ghiarone T, Brown SM, Morales-Quinones M, Ball JR, Staveley-O'Carroll KF, Aroor AR, Fadel PJ, Paradis P, Schiffrin EL, Bender SB, Martinez-Lemus LA, Padilla J. Grunewald ZI, et al. Among authors: ghiarone t. Hypertension. 2019 Dec;74(6):1409-1419. doi: 10.1161/HYPERTENSIONAHA.119.13676. Epub 2019 Oct 21. Hypertension. 2019. PMID: 31630572 Free PMC article.
LIMK (LIM Kinase) Inhibition Prevents Vasoconstriction- and Hypertension-Induced Arterial Stiffening and Remodeling.
Morales-Quinones M, Ramirez-Perez FI, Foote CA, Ghiarone T, Ferreira-Santos L, Bloksgaard M, Spencer N, Kimchi ET, Manrique-Acevedo C, Padilla J, Martinez-Lemus LA. Morales-Quinones M, et al. Among authors: ghiarone t. Hypertension. 2020 Aug;76(2):393-403. doi: 10.1161/HYPERTENSIONAHA.120.15203. Epub 2020 Jun 29. Hypertension. 2020. PMID: 32594801 Free PMC article.
Skeletal muscle microvascular insulin resistance in type 2 diabetes is not improved by eight weeks of regular walking.
Park LK, Parks EJ, Pettit-Mee RJ, Woodford ML, Ghiarone T, Smith JA, Sales ARK, Martinez-Lemus LA, Manrique-Acevedo C, Padilla J. Park LK, et al. Among authors: ghiarone t. J Appl Physiol (1985). 2020 Aug 1;129(2):283-296. doi: 10.1152/japplphysiol.00174.2020. Epub 2020 Jul 2. J Appl Physiol (1985). 2020. PMID: 32614687 Free PMC article.
Mineralocorticoid Receptor in Myeloid Cells Mediates Angiotensin II-Induced Vascular Dysfunction in Female Mice.
Manrique-Acevedo C, Padilla J, Naz H, Woodford ML, Ghiarone T, Aroor AR, Hulse JL, Cabral-Amador FJ, Martinez-Diaz V, Hans CP, Whaley-Connell A, Martinez-Lemus LA, Lastra G. Manrique-Acevedo C, et al. Among authors: ghiarone t. Front Physiol. 2021 Mar 29;12:588358. doi: 10.3389/fphys.2021.588358. eCollection 2021. Front Physiol. 2021. PMID: 33854438 Free PMC article.
Cystamine reduces vascular stiffness in Western diet-fed female mice.
Ramirez-Perez FI, Cabral-Amador FJ, Whaley-Connell AT, Aroor AR, Morales-Quinones M, Woodford ML, Ghiarone T, Ferreira-Santos L, Jurrissen TJ, Manrique-Acevedo CM, Jia G, DeMarco VG, Padilla J, Martinez-Lemus LA, Lastra G. Ramirez-Perez FI, et al. Among authors: ghiarone t. Am J Physiol Heart Circ Physiol. 2022 Feb 1;322(2):H167-H180. doi: 10.1152/ajpheart.00431.2021. Epub 2021 Dec 10. Am J Physiol Heart Circ Physiol. 2022. PMID: 34890280 Free PMC article.
SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice.
Soares RN, Ramirez-Perez FI, Cabral-Amador FJ, Morales-Quinones M, Foote CA, Ghiarone T, Sharma N, Power G, Smith JA, Rector RS, Martinez-Lemus LA, Padilla J, Manrique-Acevedo C. Soares RN, et al. Among authors: ghiarone t. Geroscience. 2022 Jun;44(3):1657-1675. doi: 10.1007/s11357-022-00563-x. Epub 2022 Apr 15. Geroscience. 2022. PMID: 35426600 Free PMC article.
20 results