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Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression.
Al-Dabet MM, Shahzad K, Elwakiel A, Sulaj A, Kopf S, Bock F, Gadi I, Zimmermann S, Rana R, Krishnan S, Gupta D, Manoharan J, Fatima S, Nazir S, Schwab C, Baber R, Scholz M, Geffers R, Mertens PR, Nawroth PP, Griffin JH, Keller M, Dockendorff C, Kohli S, Isermann B. Al-Dabet MM, et al. Among authors: griffin jh. Nat Commun. 2022 Aug 27;13(1):5062. doi: 10.1038/s41467-022-32477-9. Nat Commun. 2022. PMID: 36030260 Free PMC article.
Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes.
Madhusudhan T, Wang H, Straub BK, Gröne E, Zhou Q, Shahzad K, Müller-Krebs S, Schwenger V, Gerlitz B, Grinnell BW, Griffin JH, Reiser J, Gröne HJ, Esmon CT, Nawroth PP, Isermann B. Madhusudhan T, et al. Among authors: griffin jh. Blood. 2012 Jan 19;119(3):874-83. doi: 10.1182/blood-2011-07-365973. Epub 2011 Nov 23. Blood. 2012. PMID: 22117049 Free PMC article.
Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition.
Nazir S, Gadi I, Al-Dabet MM, Elwakiel A, Kohli S, Ghosh S, Manoharan J, Ranjan S, Bock F, Braun-Dullaeus RC, Esmon CT, Huber TB, Camerer E, Dockendorff C, Griffin JH, Isermann B, Shahzad K. Nazir S, et al. Among authors: griffin jh. Blood. 2017 Dec 14;130(24):2664-2677. doi: 10.1182/blood-2017-05-782102. Epub 2017 Sep 7. Blood. 2017. PMID: 28882883 Free PMC article.
Different DOACs Control Inflammation in Cardiac Ischemia-Reperfusion Differently.
Gadi I, Fatima S, Elwakiel A, Nazir S, Mohanad Al-Dabet M, Rana R, Bock F, Manoharan J, Gupta D, Biemann R, Nieswandt B, Braun-Dullaeus R, Besler C, Scholz M, Geffers R, Griffin JH, Esmon CT, Kohli S, Isermann B, Shahzad K. Gadi I, et al. Among authors: griffin jh. Circ Res. 2021 Feb 19;128(4):513-529. doi: 10.1161/CIRCRESAHA.120.317219. Epub 2020 Dec 23. Circ Res. 2021. PMID: 33353373 Free PMC article.
Protein C inhibitor is expressed in tubular cells of human kidney.
Radtke KP, Fernández JA, Greengard JS, Tang WW, Wilson CB, Loskutoff DJ, Scharrer I, Griffin JH. Radtke KP, et al. Among authors: griffin jh. J Clin Invest. 1994 Nov;94(5):2117-24. doi: 10.1172/JCI117566. J Clin Invest. 1994. PMID: 7525654 Free PMC article.
Activated protein C and ischemic stroke.
Griffin JH, Fernández JA, Liu D, Cheng T, Guo H, Zlokovic BV. Griffin JH, et al. Crit Care Med. 2004 May;32(5 Suppl):S247-53. doi: 10.1097/01.ccm.0000126127.87484.2b. Crit Care Med. 2004. PMID: 15118526 Review.
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