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Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression.
Al-Dabet MM, Shahzad K, Elwakiel A, Sulaj A, Kopf S, Bock F, Gadi I, Zimmermann S, Rana R, Krishnan S, Gupta D, Manoharan J, Fatima S, Nazir S, Schwab C, Baber R, Scholz M, Geffers R, Mertens PR, Nawroth PP, Griffin JH, Keller M, Dockendorff C, Kohli S, Isermann B. Al-Dabet MM, et al. Among authors: manoharan j. Nat Commun. 2022 Aug 27;13(1):5062. doi: 10.1038/s41467-022-32477-9. Nat Commun. 2022. PMID: 36030260 Free PMC article.
p45 NF-E2 regulates syncytiotrophoblast differentiation by post-translational GCM1 modifications in human intrauterine growth restriction.
Kohli S, Hoffmann J, Lochmann F, Markmeyer P, Huebner H, Fahlbusch FB, Al-Dabet MM, Gadi I, Manoharan J, Löttge M, Zenclussen AC, Aharon A, Brenner B, Shahzad K, Ruebner M, Isermann B. Kohli S, et al. Among authors: manoharan j. Cell Death Dis. 2017 Apr 6;8(4):e2730. doi: 10.1038/cddis.2017.127. Cell Death Dis. 2017. PMID: 28383551 Free PMC article.
Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function.
Madhusudhan T, Wang H, Ghosh S, Dong W, Kumar V, Al-Dabet MM, Manoharan J, Nazir S, Elwakiel A, Bock F, Kohli S, Marquardt A, Sögüt I, Shahzad K, Müller AJ, Esmon CT, Nawroth PP, Reiser J, Chavakis T, Ruf W, Isermann B. Madhusudhan T, et al. Among authors: manoharan j. Blood. 2017 Sep 21;130(12):1445-1455. doi: 10.1182/blood-2017-02-767921. Epub 2017 Jul 7. Blood. 2017. PMID: 28687614 Free PMC article.
Farnesoid X Receptor Agonism Protects against Diabetic Tubulopathy: Potential Add-On Therapy for Diabetic Nephropathy.
Marquardt A, Al-Dabet MM, Ghosh S, Kohli S, Manoharan J, ElWakiel A, Gadi I, Bock F, Nazir S, Wang H, Lindquist JA, Nawroth PP, Madhusudhan T, Mertens PR, Shahzad K, Isermann B. Marquardt A, et al. Among authors: manoharan j. J Am Soc Nephrol. 2017 Nov;28(11):3182-3189. doi: 10.1681/ASN.2016101123. Epub 2017 Jul 10. J Am Soc Nephrol. 2017. PMID: 28696246 Free PMC article.
Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition.
Nazir S, Gadi I, Al-Dabet MM, Elwakiel A, Kohli S, Ghosh S, Manoharan J, Ranjan S, Bock F, Braun-Dullaeus RC, Esmon CT, Huber TB, Camerer E, Dockendorff C, Griffin JH, Isermann B, Shahzad K. Nazir S, et al. Among authors: manoharan j. Blood. 2017 Dec 14;130(24):2664-2677. doi: 10.1182/blood-2017-05-782102. Epub 2017 Sep 7. Blood. 2017. PMID: 28882883 Free PMC article.
Different DOACs Control Inflammation in Cardiac Ischemia-Reperfusion Differently.
Gadi I, Fatima S, Elwakiel A, Nazir S, Mohanad Al-Dabet M, Rana R, Bock F, Manoharan J, Gupta D, Biemann R, Nieswandt B, Braun-Dullaeus R, Besler C, Scholz M, Geffers R, Griffin JH, Esmon CT, Kohli S, Isermann B, Shahzad K. Gadi I, et al. Among authors: manoharan j. Circ Res. 2021 Feb 19;128(4):513-529. doi: 10.1161/CIRCRESAHA.120.317219. Epub 2020 Dec 23. Circ Res. 2021. PMID: 33353373 Free PMC article.
Hypercoagulability Impairs Plaque Stability in Diabetes-Induced Atherosclerosis.
Ambreen S, Fatima S, Elwakiel A, Rana R, Singh K, Gupta A, Gupta D, Khawaja H, Manoharan J, Besler C, Laufs U, Kohli S, Isermann B, Shahzad K. Ambreen S, et al. Among authors: manoharan j. Nutrients. 2022 May 10;14(10):1991. doi: 10.3390/nu14101991. Nutrients. 2022. PMID: 35631132 Free PMC article.
CD248 induces a maladaptive unfolded protein response in diabetic kidney disease.
Krishnan S, Manoharan J, Wang H, Gupta D, Fatima S, Yu Y, Mathew A, Li Z, Kohli S, Schwab C, Körner A, Mertens PR, Nawroth P, Shahzad K, Naumann M, Isermann B, Biemann R. Krishnan S, et al. Among authors: manoharan j. Kidney Int. 2023 Feb;103(2):304-319. doi: 10.1016/j.kint.2022.09.024. Epub 2022 Oct 26. Kidney Int. 2023. PMID: 36309126 Free article.
61 results