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Reversal of the renal hyperglycemic memory in diabetic kidney disease by targeting sustained tubular p21 expression.
Al-Dabet MM, Shahzad K, Elwakiel A, Sulaj A, Kopf S, Bock F, Gadi I, Zimmermann S, Rana R, Krishnan S, Gupta D, Manoharan J, Fatima S, Nazir S, Schwab C, Baber R, Scholz M, Geffers R, Mertens PR, Nawroth PP, Griffin JH, Keller M, Dockendorff C, Kohli S, Isermann B. Al-Dabet MM, et al. Among authors: nazir s. Nat Commun. 2022 Aug 27;13(1):5062. doi: 10.1038/s41467-022-32477-9. Nat Commun. 2022. PMID: 36030260 Free PMC article.
Activated protein C reverses epigenetically sustained p66Shc expression in plaque-associated macrophages in diabetes.
Shahzad K, Gadi I, Nazir S, Al-Dabet MM, Kohli S, Bock F, Breitenstein L, Ranjan S, Fuchs T, Halloul Z, Nawroth PP, Pelicci PG, Braun-Dullaeus RC, Camerer E, Esmon CT, Isermann B. Shahzad K, et al. Among authors: nazir s. Commun Biol. 2018 Aug 6;1:104. doi: 10.1038/s42003-018-0108-5. eCollection 2018. Commun Biol. 2018. PMID: 30271984 Free PMC article.
Caspase-1, but Not Caspase-3, Promotes Diabetic Nephropathy.
Shahzad K, Bock F, Al-Dabet MM, Gadi I, Kohli S, Nazir S, Ghosh S, Ranjan S, Wang H, Madhusudhan T, Nawroth PP, Isermann B. Shahzad K, et al. Among authors: nazir s. J Am Soc Nephrol. 2016 Aug;27(8):2270-5. doi: 10.1681/ASN.2015060676. Epub 2016 Feb 1. J Am Soc Nephrol. 2016. PMID: 26832955 Free PMC article.
Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function.
Madhusudhan T, Wang H, Ghosh S, Dong W, Kumar V, Al-Dabet MM, Manoharan J, Nazir S, Elwakiel A, Bock F, Kohli S, Marquardt A, Sögüt I, Shahzad K, Müller AJ, Esmon CT, Nawroth PP, Reiser J, Chavakis T, Ruf W, Isermann B. Madhusudhan T, et al. Among authors: nazir s. Blood. 2017 Sep 21;130(12):1445-1455. doi: 10.1182/blood-2017-02-767921. Epub 2017 Jul 7. Blood. 2017. PMID: 28687614 Free PMC article.
Farnesoid X Receptor Agonism Protects against Diabetic Tubulopathy: Potential Add-On Therapy for Diabetic Nephropathy.
Marquardt A, Al-Dabet MM, Ghosh S, Kohli S, Manoharan J, ElWakiel A, Gadi I, Bock F, Nazir S, Wang H, Lindquist JA, Nawroth PP, Madhusudhan T, Mertens PR, Shahzad K, Isermann B. Marquardt A, et al. Among authors: nazir s. J Am Soc Nephrol. 2017 Nov;28(11):3182-3189. doi: 10.1681/ASN.2016101123. Epub 2017 Jul 10. J Am Soc Nephrol. 2017. PMID: 28696246 Free PMC article.
Cytoprotective activated protein C averts Nlrp3 inflammasome-induced ischemia-reperfusion injury via mTORC1 inhibition.
Nazir S, Gadi I, Al-Dabet MM, Elwakiel A, Kohli S, Ghosh S, Manoharan J, Ranjan S, Bock F, Braun-Dullaeus RC, Esmon CT, Huber TB, Camerer E, Dockendorff C, Griffin JH, Isermann B, Shahzad K. Nazir S, et al. Blood. 2017 Dec 14;130(24):2664-2677. doi: 10.1182/blood-2017-05-782102. Epub 2017 Sep 7. Blood. 2017. PMID: 28882883 Free PMC article.
Podocyte Integrin-β3 and Activated Protein C Coordinately Restrict RhoA Signaling and Ameliorate Diabetic Nephropathy.
Madhusudhan T, Ghosh S, Wang H, Dong W, Gupta D, Elwakiel A, Stoyanov S, Al-Dabet MM, Krishnan S, Biemann R, Nazir S, Zimmermann S, Mathew A, Gadi I, Rana R, Zeng-Brouwers J, Moeller MJ, Schaefer L, Esmon CT, Kohli S, Reiser J, Rezaie AR, Ruf W, Isermann B. Madhusudhan T, et al. Among authors: nazir s. J Am Soc Nephrol. 2020 Aug;31(8):1762-1780. doi: 10.1681/ASN.2019111163. Epub 2020 Jul 24. J Am Soc Nephrol. 2020. PMID: 32709711 Free PMC article.
Different DOACs Control Inflammation in Cardiac Ischemia-Reperfusion Differently.
Gadi I, Fatima S, Elwakiel A, Nazir S, Mohanad Al-Dabet M, Rana R, Bock F, Manoharan J, Gupta D, Biemann R, Nieswandt B, Braun-Dullaeus R, Besler C, Scholz M, Geffers R, Griffin JH, Esmon CT, Kohli S, Isermann B, Shahzad K. Gadi I, et al. Among authors: nazir s. Circ Res. 2021 Feb 19;128(4):513-529. doi: 10.1161/CIRCRESAHA.120.317219. Epub 2020 Dec 23. Circ Res. 2021. PMID: 33353373 Free PMC article.
Maternal extracellular vesicles and platelets promote preeclampsia via inflammasome activation in trophoblasts.
Kohli S, Ranjan S, Hoffmann J, Kashif M, Daniel EA, Al-Dabet MM, Bock F, Nazir S, Huebner H, Mertens PR, Fischer KD, Zenclussen AC, Offermanns S, Aharon A, Brenner B, Shahzad K, Ruebner M, Isermann B. Kohli S, et al. Among authors: nazir s. Blood. 2016 Oct 27;128(17):2153-2164. doi: 10.1182/blood-2016-03-705434. Epub 2016 Sep 2. Blood. 2016. PMID: 27589872 Free article.
554 results