Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity.
Choi ML, Chappard A, Singh BP, Maclachlan C, Rodrigues M, Fedotova EI, Berezhnov AV, De S, Peddie CJ, Athauda D, Virdi GS, Zhang W, Evans JR, Wernick AI, Zanjani ZS, Angelova PR, Esteras N, Vinokurov AY, Morris K, Jeacock K, Tosatto L, Little D, Gissen P, Clarke DJ, Kunath T, Collinson L, Klenerman D, Abramov AY, Horrocks MH, Gandhi S.
Choi ML, et al. Among authors: de s.
Nat Neurosci. 2022 Sep;25(9):1134-1148. doi: 10.1038/s41593-022-01140-3. Epub 2022 Aug 30.
Nat Neurosci. 2022.
PMID: 36042314
Free PMC article.
Aggregation of alpha-synuclein (alpha-Syn) drives Parkinson's disease (PD), although the initial stages of self-assembly and structural conversion have not been directly observed inside neurons. ...These processes were also observed in induced pluripotent stem cell (iPSC)- …
Aggregation of alpha-synuclein (alpha-Syn) drives Parkinson's disease (PD), although the initial stages of self-assembly and structur …