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Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity.
Choi ML, Chappard A, Singh BP, Maclachlan C, Rodrigues M, Fedotova EI, Berezhnov AV, De S, Peddie CJ, Athauda D, Virdi GS, Zhang W, Evans JR, Wernick AI, Zanjani ZS, Angelova PR, Esteras N, Vinokurov AY, Morris K, Jeacock K, Tosatto L, Little D, Gissen P, Clarke DJ, Kunath T, Collinson L, Klenerman D, Abramov AY, Horrocks MH, Gandhi S. Choi ML, et al. Among authors: horrocks mh. Nat Neurosci. 2022 Sep;25(9):1134-1148. doi: 10.1038/s41593-022-01140-3. Epub 2022 Aug 30. Nat Neurosci. 2022. PMID: 36042314 Free PMC article.
Single molecule fluorescence under conditions of fast flow.
Horrocks MH, Li H, Shim JU, Ranasinghe RT, Clarke RW, Huck WT, Abell C, Klenerman D. Horrocks MH, et al. Anal Chem. 2012 Jan 3;84(1):179-85. doi: 10.1021/ac202313d. Epub 2011 Dec 6. Anal Chem. 2012. PMID: 22147688
Lipid peroxidation is essential for α-synuclein-induced cell death.
Angelova PR, Horrocks MH, Klenerman D, Gandhi S, Abramov AY, Shchepinov MS. Angelova PR, et al. Among authors: horrocks mh. J Neurochem. 2015 May;133(4):582-9. doi: 10.1111/jnc.13024. Epub 2015 Mar 1. J Neurochem. 2015. PMID: 25580849 Free PMC article.
58 results