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From a Cone Snail Toxin to a Competitive MC4R Antagonist.
J Med Chem. 2022 Sep 22;65(18):12084-12094. doi: 10.1021/acs.jmedchem.2c00786. Epub 2022 Sep 5.
J Med Chem. 2022.
PMID: 36063022
Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation.
Brouwers B, de Oliveira EM, Marti-Solano M, Monteiro FBF, Laurin SA, Keogh JM, Henning E, Bounds R, Daly CA, Houston S, Ayinampudi V, Wasiluk N, Clarke D, Plouffe B, Bouvier M, Babu MM, Farooqi IS, Mokrosiński J.
Brouwers B, et al. Among authors: laurin sa.
Cell Rep. 2021 Mar 23;34(12):108862. doi: 10.1016/j.celrep.2021.108862.
Cell Rep. 2021.
PMID: 33761344
Free PMC article.
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