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From a Cone Snail Toxin to a Competitive MC4R Antagonist.
Reynaud S, Laurin SA, Ciolek J, Barbe P, Van Baelen AC, Susset M, Blondel F, Ghazarian M, Boeri J, Vanden Driessche M, Upert G, Mourier G, Kessler P, Konnert L, Beroud R, Keck M, Servent D, Bouvier M, Gilles N. Reynaud S, et al. Among authors: upert g. J Med Chem. 2022 Sep 22;65(18):12084-12094. doi: 10.1021/acs.jmedchem.2c00786. Epub 2022 Sep 5. J Med Chem. 2022. PMID: 36063022
A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists.
Reynaud S, Ciolek J, Degueldre M, Saez NJ, Sequeira AF, Duhoo Y, Brás JLA, Meudal H, Cabo Díez M, Fernández Pedrosa V, Verdenaud M, Boeri J, Pereira Ramos O, Ducancel F, Vanden Driessche M, Fourmy R, Violette A, Upert G, Mourier G, Beck-Sickinger AG, Mörl K, Landon C, Fontes CMGA, Miñambres Herráiz R, Rodríguez de la Vega RC, Peigneur S, Tytgat J, Quinton L, De Pauw E, Vincentelli R, Servent D, Gilles N. Reynaud S, et al. Among authors: upert g. J Med Chem. 2020 Aug 13;63(15):8250-8264. doi: 10.1021/acs.jmedchem.0c00485. Epub 2020 Jul 16. J Med Chem. 2020. PMID: 32602722
A new Kunitz-type snake toxin family associated with an original mode of interaction with the vasopressin 2 receptor.
Droctové L, Ciolek J, Mendre C, Chorfa A, Huerta P, Carvalho C, Gouin C, Lancien M, Stanajic-Petrovic G, Braco L, Blanchet G, Upert G, De Pauw G, Barbe P, Keck M, Mourier G, Mouillac B, Denis S, Rodríguez de la Vega RC, Quinton L, Gilles N. Droctové L, et al. Among authors: upert g. Br J Pharmacol. 2022 Jul;179(13):3470-3481. doi: 10.1111/bph.15814. Epub 2022 Feb 28. Br J Pharmacol. 2022. PMID: 35122240 Free article.
High-throughput production of two disulphide-bridge toxins.
Upert G, Mourier G, Pastor A, Verdenaud M, Alili D, Servent D, Gilles N. Upert G, et al. Chem Commun (Camb). 2014 Aug 7;50(61):8408-11. doi: 10.1039/c4cc02679a. Chem Commun (Camb). 2014. PMID: 24947561
Identification, structural and pharmacological characterization of τ-CnVA, a conopeptide that selectively interacts with somatostatin sst3 receptor.
Petrel C, Hocking HG, Reynaud M, Upert G, Favreau P, Biass D, Paolini-Bertrand M, Peigneur S, Tytgat J, Gilles N, Hartley O, Boelens R, Stocklin R, Servent D. Petrel C, et al. Among authors: upert g. Biochem Pharmacol. 2013 Jun 1;85(11):1663-71. doi: 10.1016/j.bcp.2013.03.019. Epub 2013 Apr 5. Biochem Pharmacol. 2013. PMID: 23567999
Combination of Capillary Zone Electrophoresis-Mass Spectrometry, Ion Mobility-Mass Spectrometry, and Theoretical Calculations for Cysteine Connectivity Identification in Peptides Bearing Two Intramolecular Disulfide Bonds.
Delvaux C, Massonnet P, Kune C, Haler JRN, Upert G, Mourier G, Gilles N, Quinton L, De Pauw E, Far J. Delvaux C, et al. Among authors: upert g. Anal Chem. 2020 Feb 4;92(3):2425-2434. doi: 10.1021/acs.analchem.9b03206. Epub 2020 Jan 13. Anal Chem. 2020. PMID: 31885261
29 results