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A phase I trial of the HIV protease inhibitor nelfinavir in adults with solid tumors.
Blumenthal GM, Gills JJ, Ballas MS, Bernstein WB, Komiya T, Dechowdhury R, Morrow B, Root H, Chun G, Helsabeck C, Steinberg SM, LoPiccolo J, Kawabata S, Gardner ER, Figg WD, Dennis PA. Blumenthal GM, et al. Among authors: kawabata s. Oncotarget. 2014 Sep 30;5(18):8161-72. doi: 10.18632/oncotarget.2415. Oncotarget. 2014. PMID: 25327558 Free PMC article. Clinical Trial.
Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo.
Gills JJ, Lopiccolo J, Tsurutani J, Shoemaker RH, Best CJ, Abu-Asab MS, Borojerdi J, Warfel NA, Gardner ER, Danish M, Hollander MC, Kawabata S, Tsokos M, Figg WD, Steeg PS, Dennis PA. Gills JJ, et al. Among authors: kawabata s. Clin Cancer Res. 2007 Sep 1;13(17):5183-94. doi: 10.1158/1078-0432.CCR-07-0161. Clin Cancer Res. 2007. PMID: 17785575
Metformin prevents tobacco carcinogen--induced lung tumorigenesis.
Memmott RM, Mercado JR, Maier CR, Kawabata S, Fox SD, Dennis PA. Memmott RM, et al. Among authors: kawabata s. Cancer Prev Res (Phila). 2010 Sep;3(9):1066-76. doi: 10.1158/1940-6207.CAPR-10-0055. Epub 2010 Sep 1. Cancer Prev Res (Phila). 2010. PMID: 20810672 Free PMC article.
957 results