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Targeting the Cbl-b-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cell responses.
Monticone G, Huang Z, Csibi F, Leit S, Ciccone D, Champhekar AS, Austin JE, Ucar DA, Hossain F, Ibba SV, Boulares AH, Carpino N, Xu K, Majumder S, Osborne BA, Loh C, Miele L. Monticone G, et al. Among authors: ibba sv. Front Immunol. 2022 Aug 26;13:987298. doi: 10.3389/fimmu.2022.987298. eCollection 2022. Front Immunol. 2022. PMID: 36090975 Free PMC article.
Targeting PARP-1 with metronomic therapy modulates MDSC suppressive function and enhances anti-PD-1 immunotherapy in colon cancer.
Ghonim MA, Ibba SV, Tarhuni AF, Errami Y, Luu HH, Dean MJ, El-Bahrawy AH, Wyczechowska D, Benslimane IA, Del Valle L, Al-Khami AA, Ochoa AC, Boulares AH. Ghonim MA, et al. Among authors: ibba sv. J Immunother Cancer. 2021 Jan;9(1):e001643. doi: 10.1136/jitc-2020-001643. J Immunother Cancer. 2021. PMID: 33495297 Free PMC article.
Fuelling the mechanisms of asthma: Increased fatty acid oxidation in inflammatory immune cells may represent a novel therapeutic target.
Al-Khami AA, Ghonim MA, Del Valle L, Ibba SV, Zheng L, Pyakurel K, Okpechi SC, Garay J, Wyczechowska D, Sanchez-Pino MD, Rodriguez PC, Boulares AH, Ochoa AC. Al-Khami AA, et al. Among authors: ibba sv. Clin Exp Allergy. 2017 Sep;47(9):1170-1184. doi: 10.1111/cea.12947. Epub 2017 Jul 5. Clin Exp Allergy. 2017. PMID: 28456994 Free PMC article.
Treatment with intranasal iloprost reduces disease manifestations in a murine model of previously established COPD.
Lammi MR, Ghonim MA, Pyakurel K, Naura AS, Ibba SV, Davis CJ, Okpechi SC, Happel KI, deBoisblanc BP, Shellito J, Boulares AH. Lammi MR, et al. Among authors: ibba sv. Am J Physiol Lung Cell Mol Physiol. 2016 Apr 1;310(7):L630-8. doi: 10.1152/ajplung.00297.2015. Epub 2016 Feb 5. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 26851260 Free PMC article.
PARP is activated in human asthma and its inhibition by olaparib blocks house dust mite-induced disease in mice.
Ghonim MA, Pyakurel K, Ibba SV, Wang J, Rodriguez P, Al-Khami AA, Lammi MR, Kim H, Zea AH, Davis C, Okpechi S, Wyczechowska D, Al-Ghareeb K, Mansy MS, Ochoa A, Naura AS, Boulares AH. Ghonim MA, et al. Among authors: ibba sv. Clin Sci (Lond). 2015 Dec;129(11):951-62. doi: 10.1042/CS20150122. Epub 2015 Jul 23. Clin Sci (Lond). 2015. PMID: 26205779 Free PMC article.
Corrigendum: Endoplasmic Reticulum Associated Aminopeptidase 2 (ERAP2) Is Released in the Secretome of Activated MDMs and Reduces in vitro HIV-1 Infection.
Saulle I, Ibba SV, Torretta E, Vittori C, Fenizia C, Piancone F, Minisci D, Lori EM, Trabattoni D, Gelfi C, Clerici M, Biasin M. Saulle I, et al. Among authors: ibba sv. Front Immunol. 2019 Dec 6;10:2838. doi: 10.3389/fimmu.2019.02838. eCollection 2019. Front Immunol. 2019. PMID: 31853242 Free PMC article.
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