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Cohesin is required for long-range enhancer action at the Shh locus.
Kane L, Williamson I, Flyamer IM, Kumar Y, Hill RE, Lettice LA, Bickmore WA. Kane L, et al. Nat Struct Mol Biol. 2022 Sep;29(9):891-897. doi: 10.1038/s41594-022-00821-8. Epub 2022 Sep 12. Nat Struct Mol Biol. 2022. PMID: 36097291 Free PMC article.
Decreased Enhancer-Promoter Proximity Accompanying Enhancer Activation.
Benabdallah NS, Williamson I, Illingworth RS, Kane L, Boyle S, Sengupta D, Grimes GR, Therizols P, Bickmore WA. Benabdallah NS, et al. Among authors: kane l. Mol Cell. 2019 Nov 7;76(3):473-484.e7. doi: 10.1016/j.molcel.2019.07.038. Epub 2019 Sep 4. Mol Cell. 2019. PMID: 31494034 Free PMC article.
Developmentally regulated Shh expression is robust to TAD perturbations.
Williamson I, Kane L, Devenney PS, Flyamer IM, Anderson E, Kilanowski F, Hill RE, Bickmore WA, Lettice LA. Williamson I, et al. Among authors: kane l. Development. 2019 Sep 30;146(19):dev179523. doi: 10.1242/dev.179523. Development. 2019. PMID: 31511252 Free PMC article.
Deletion of CTCF sites in the SHH locus alters enhancer-promoter interactions and leads to acheiropodia.
Ushiki A, Zhang Y, Xiong C, Zhao J, Georgakopoulos-Soares I, Kane L, Jamieson K, Bamshad MJ, Nickerson DA; University of Washington Center for Mendelian Genomics; Shen Y, Lettice LA, Silveira-Lucas EL, Petit F, Ahituv N. Ushiki A, et al. Among authors: kane l. Nat Commun. 2021 Apr 16;12(1):2282. doi: 10.1038/s41467-021-22470-z. Nat Commun. 2021. PMID: 33863876 Free PMC article.
444 results