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Homologous recombination-deficient mutation cluster in tumor suppressor RAD51C identified by comprehensive analysis of cancer variants.
Prakash R, Rawal Y, Sullivan MR, Grundy MK, Bret H, Mihalevic MJ, Rein HL, Baird JM, Darrah K, Zhang F, Wang R, Traina TA, Radke MR, Kaufmann SH, Swisher EM, Guérois R, Modesti M, Sung P, Jasin M, Bernstein KA. Prakash R, et al. Among authors: grundy mk. Proc Natl Acad Sci U S A. 2022 Sep 20;119(38):e2202727119. doi: 10.1073/pnas.2202727119. Epub 2022 Sep 13. Proc Natl Acad Sci U S A. 2022. PMID: 36099300 Free PMC article.
RAD51D splice variants and cancer-associated mutations reveal XRCC2 interaction to be critical for homologous recombination.
Baldock RA, Pressimone CA, Baird JM, Khodakov A, Luong TT, Grundy MK, Smith CM, Karpenshif Y, Bratton-Palmer DS, Prakash R, Jasin M, Garcin EB, Gon S, Modesti M, Bernstein KA. Baldock RA, et al. Among authors: grundy mk. DNA Repair (Amst). 2019 Apr;76:99-107. doi: 10.1016/j.dnarep.2019.02.008. Epub 2019 Feb 23. DNA Repair (Amst). 2019. PMID: 30836272 Free PMC article.
RAD51 Gene Family Structure and Function.
Bonilla B, Hengel SR, Grundy MK, Bernstein KA. Bonilla B, et al. Among authors: grundy mk. Annu Rev Genet. 2020 Nov 23;54:25-46. doi: 10.1146/annurev-genet-021920-092410. Epub 2020 Jul 14. Annu Rev Genet. 2020. PMID: 32663049 Free PMC article. Review.
The CHARGE syndrome ortholog CHD-7 regulates TGF-β pathways in Caenorhabditis elegans.
Jofré DM, Hoffman DK, Cervino AS, Hahn GM, Grundy M, Yun S, Amrit FRG, Stolz DB, Godoy LF, Salvatore E, Rossi FA, Ghazi A, Cirio MC, Yanowitz JL, Hochbaum D. Jofré DM, et al. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2109508119. doi: 10.1073/pnas.2109508119. Epub 2022 Apr 8. Proc Natl Acad Sci U S A. 2022. PMID: 35394881 Free PMC article.