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Nanobodies identify an activated state of the TRIB2 pseudokinase.
Jamieson SA, Pudjihartono M, Horne CR, Viloria JS, Dunlop JL, McMillan HD, Day RC, Keeshan K, Murphy JM, Mace PD. Jamieson SA, et al. Among authors: horne cr. Structure. 2022 Nov 3;30(11):1518-1529.e5. doi: 10.1016/j.str.2022.08.006. Epub 2022 Sep 14. Structure. 2022. PMID: 36108635 Free article.
A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells.
Samson AL, Fitzgibbon C, Patel KM, Hildebrand JM, Whitehead LW, Rimes JS, Jacobsen AV, Horne CR, Gavin XJ, Young SN, Rogers KL, Hawkins ED, Murphy JM. Samson AL, et al. Among authors: horne cr. Cell Death Differ. 2021 Jul;28(7):2126-2144. doi: 10.1038/s41418-021-00742-x. Epub 2021 Feb 15. Cell Death Differ. 2021. PMID: 33589776 Free PMC article.
Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.
Garnish SE, Meng Y, Koide A, Sandow JJ, Denbaum E, Jacobsen AV, Yeung W, Samson AL, Horne CR, Fitzgibbon C, Young SN, Smith PPC, Webb AI, Petrie EJ, Hildebrand JM, Kannan N, Czabotar PE, Koide S, Murphy JM. Garnish SE, et al. Among authors: horne cr. Nat Commun. 2021 Apr 13;12(1):2211. doi: 10.1038/s41467-021-22400-z. Nat Commun. 2021. PMID: 33850121 Free PMC article.
Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL.
Sethi A, Horne CR, Fitzgibbon C, Wilde K, Davies KA, Garnish SE, Jacobsen AV, Samson AL, Hildebrand JM, Wardak A, Czabotar PE, Petrie EJ, Gooley PR, Murphy JM. Sethi A, et al. Among authors: horne cr. Cell Death Differ. 2022 Sep;29(9):1804-1815. doi: 10.1038/s41418-022-00965-6. Epub 2022 Mar 9. Cell Death Differ. 2022. PMID: 35264780 Free PMC article.
39 results