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A cellular hierarchy in melanoma uncouples growth and metastasis.
Karras P, Bordeu I, Pozniak J, Nowosad A, Pazzi C, Van Raemdonck N, Landeloos E, Van Herck Y, Pedri D, Bervoets G, Makhzami S, Khoo JH, Pavie B, Lamote J, Marin-Bejar O, Dewaele M, Liang H, Zhang X, Hua Y, Wouters J, Browaeys R, Bergers G, Saeys Y, Bosisio F, van den Oord J, Lambrechts D, Rustgi AK, Bechter O, Blanpain C, Simons BD, Rambow F, Marine JC. Karras P, et al. Among authors: lambrechts d. Nature. 2022 Oct;610(7930):190-198. doi: 10.1038/s41586-022-05242-7. Epub 2022 Sep 21. Nature. 2022. PMID: 36131018 Free PMC article.
Gain of function of mutant p53 by coaggregation with multiple tumor suppressors.
Xu J, Reumers J, Couceiro JR, De Smet F, Gallardo R, Rudyak S, Cornelis A, Rozenski J, Zwolinska A, Marine JC, Lambrechts D, Suh YA, Rousseau F, Schymkowitz J. Xu J, et al. Among authors: lambrechts d. Nat Chem Biol. 2011 May;7(5):285-95. doi: 10.1038/nchembio.546. Epub 2011 Mar 27. Nat Chem Biol. 2011. PMID: 21445056
p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity.
Adriaens C, Standaert L, Barra J, Latil M, Verfaillie A, Kalev P, Boeckx B, Wijnhoven PW, Radaelli E, Vermi W, Leucci E, Lapouge G, Beck B, van den Oord J, Nakagawa S, Hirose T, Sablina AA, Lambrechts D, Aerts S, Blanpain C, Marine JC. Adriaens C, et al. Among authors: lambrechts d. Nat Med. 2016 Aug;22(8):861-8. doi: 10.1038/nm.4135. Epub 2016 Jul 4. Nat Med. 2016. PMID: 27376578
Tumour hypoxia causes DNA hypermethylation by reducing TET activity.
Thienpont B, Steinbacher J, Zhao H, D'Anna F, Kuchnio A, Ploumakis A, Ghesquière B, Van Dyck L, Boeckx B, Schoonjans L, Hermans E, Amant F, Kristensen VN, Peng Koh K, Mazzone M, Coleman M, Carell T, Carmeliet P, Lambrechts D. Thienpont B, et al. Among authors: d anna f, lambrechts d. Nature. 2016 Sep 1;537(7618):63-68. doi: 10.1038/nature19081. Epub 2016 Aug 17. Nature. 2016. PMID: 27533040 Free PMC article.
Expression profiling of budding cells in colorectal cancer reveals an EMT-like phenotype and molecular subtype switching.
De Smedt L, Palmans S, Andel D, Govaere O, Boeckx B, Smeets D, Galle E, Wouters J, Barras D, Suffiotti M, Dekervel J, Tousseyn T, De Hertogh G, Prenen H, Tejpar S, Lambrechts D, Sagaert X. De Smedt L, et al. Among authors: lambrechts d. Br J Cancer. 2017 Jan 3;116(1):58-65. doi: 10.1038/bjc.2016.382. Epub 2016 Nov 24. Br J Cancer. 2017. PMID: 27884016 Free PMC article.
The role of fatty acid β-oxidation in lymphangiogenesis.
Wong BW, Wang X, Zecchin A, Thienpont B, Cornelissen I, Kalucka J, García-Caballero M, Missiaen R, Huang H, Brüning U, Blacher S, Vinckier S, Goveia J, Knobloch M, Zhao H, Dierkes C, Shi C, Hägerling R, Moral-Dardé V, Wyns S, Lippens M, Jessberger S, Fendt SM, Luttun A, Noel A, Kiefer F, Ghesquière B, Moons L, Schoonjans L, Dewerchin M, Eelen G, Lambrechts D, Carmeliet P. Wong BW, et al. Among authors: lambrechts d. Nature. 2017 Feb 2;542(7639):49-54. doi: 10.1038/nature21028. Epub 2016 Dec 26. Nature. 2017. PMID: 28024299
Comparative oncogenomics identifies tyrosine kinase FES as a tumor suppressor in melanoma.
Olvedy M, Tisserand JC, Luciani F, Boeckx B, Wouters J, Lopez S, Rambow F, Aibar S, Thienpont B, Barra J, Köhler C, Radaelli E, Tartare-Deckert S, Aerts S, Dubreuil P, van den Oord JJ, Lambrechts D, De Sepulveda P, Marine JC. Olvedy M, et al. Among authors: lambrechts d. J Clin Invest. 2017 Jun 1;127(6):2310-2325. doi: 10.1172/JCI91291. Epub 2017 May 2. J Clin Invest. 2017. PMID: 28463229 Free PMC article.
604 results