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A specialized metabolic pathway partitions citrate in hydroxyapatite to impact mineralization of bones and teeth.
Dirckx N, Zhang Q, Chu EY, Tower RJ, Li Z, Guo S, Yuan S, Khare PA, Zhang C, Verardo A, Alejandro LO, Park A, Faugere MC, Helfand SL, Somerman MJ, Riddle RC, de Cabo R, Le A, Schmidt-Rohr K, Clemens TL. Dirckx N, et al. Among authors: tower rj. Proc Natl Acad Sci U S A. 2022 Nov 8;119(45):e2212178119. doi: 10.1073/pnas.2212178119. Epub 2022 Nov 2. Proc Natl Acad Sci U S A. 2022. PMID: 36322718 Free PMC article.
NGF-TrkA signaling dictates neural ingrowth and aberrant osteochondral differentiation after soft tissue trauma.
Lee S, Hwang C, Marini S, Tower RJ, Qin Q, Negri S, Pagani CA, Sun Y, Stepien DM, Sorkin M, Kubiak CA, Visser ND, Meyers CA, Wang Y, Rasheed HA, Xu J, Miller S, Huber AK, Minichiello L, Cederna PS, Kemp SWP, Clemens TL, James AW, Levi B. Lee S, et al. Among authors: tower rj. Nat Commun. 2021 Aug 16;12(1):4939. doi: 10.1038/s41467-021-25143-z. Nat Commun. 2021. PMID: 34400627 Free PMC article.
Discoidin domain receptor 2 regulates aberrant mesenchymal lineage cell fate and matrix organization.
Pagani CA, Bancroft AC, Tower RJ, Livingston N, Sun Y, Hong JY, Kent RN 3rd, Strong AL, Nunez JH, Medrano JMR, Patel N, Nanes BA, Dean KM, Li Z, Ge C, Baker BM, James AW, Weiss SJ, Franceschi RT, Levi B. Pagani CA, et al. Among authors: tower rj. Sci Adv. 2022 Dec 21;8(51):eabq6152. doi: 10.1126/sciadv.abq6152. Epub 2022 Dec 21. Sci Adv. 2022. PMID: 36542719 Free PMC article.
TrkA-mediated sensory innervation of injured mouse tendon supports tendon sheath progenitor cell expansion and tendon repair.
Cherief M, Xu J, Li Z, Tower RJ, Ramesh S, Qin Q, Gomez-Salazar M, Yea JH, Lee S, Negri S, Xu M, Price T, Kendal AR, Fan CM, Clemens TL, Levi B, James AW. Cherief M, et al. Among authors: tower rj. Sci Transl Med. 2023 Dec 20;15(727):eade4619. doi: 10.1126/scitranslmed.ade4619. Epub 2023 Dec 20. Sci Transl Med. 2023. PMID: 38117901
55 results