Abou-Gharbia M - Search Results

1

Effects of a Novel Beta Lactam Compound, MC-100093, on the Expression of Glutamate Transporters/Receptors and Ethanol Drinking Behavior of Alcohol-Preferring Rats.

Alhaddad H, Wong W, Abou-Gharbia M, Childers W, Melenski E, Bell RL, Sari Y. Alhaddad H, et al. Among authors: abou gharbia m. J Pharmacol Exp Ther. 2022 Dec;383(3):208-216. doi: 10.1124/jpet.122.001147. Epub 2022 Sep 24. J Pharmacol Exp Ther. 2022. PMID: 36153003 Free PMC article.

2

MC-100093, a Novel β-Lactam Glutamate Transporter-1 Enhancer Devoid of Antimicrobial Properties, Attenuates Cocaine Relapse in Rats.

Knackstedt LA, Wu L, Rothstein J, Vidensky S, Gordon J, Ramanjulu M, Dunman P, Blass B, Childers W, Abou-Gharbia M. Knackstedt LA, et al. Among authors: abou gharbia m. J Pharmacol Exp Ther. 2021 Aug;378(2):51-59. doi: 10.1124/jpet.121.000532. Epub 2021 May 13. J Pharmacol Exp Ther. 2021. PMID: 33986035 Free PMC article.

3

Discovery of innovative therapeutics: today's realities and tomorrow's vision. 2. Pharma's challenges and their commitment to innovation.

Abou-Gharbia M, Childers WE. Abou-Gharbia M, et al. J Med Chem. 2014 Jul 10;57(13):5525-53. doi: 10.1021/jm401564r. Epub 2014 Feb 7. J Med Chem. 2014. PMID: 24428137

4

"I'll Be Back": The Resurrection of Dezocine.

Childers WE, Abou-Gharbia MA. Childers WE, et al. Among authors: abou gharbia ma. ACS Med Chem Lett. 2021 May 19;12(6):961-968. doi: 10.1021/acsmedchemlett.1c00233. eCollection 2021 Jun 10. ACS Med Chem Lett. 2021. PMID: 34141081 Free PMC article.

5

Discovery of innovative therapeutics: today's realities and tomorrow's vision. 1. Criticisms faced by the pharmaceutical industry.

Abou-Gharbia M, Childers WE. Abou-Gharbia M, et al. J Med Chem. 2013 Jul 25;56(14):5659-72. doi: 10.1021/jm400330j. Epub 2013 Apr 29. J Med Chem. 2013. PMID: 23557017

6

Novel compounds that reverse the disease phenotype in Type 2 Gaucher disease patient-derived cells.

Childers W, Fan R, Martinez R, Colussi DJ, Melenski E, Liu Y, Gordon J, Abou-Gharbia M, Jacobson MA. Childers W, et al. Bioorg Med Chem Lett. 2020 Jan 15;30(2):126806. doi: 10.1016/j.bmcl.2019.126806. Epub 2019 Nov 11. Bioorg Med Chem Lett. 2020. PMID: 31757667 Free PMC article.

7

The Resurrection of Phenotypic Drug Discovery.

Childers WE, Elokely KM, Abou-Gharbia M. Childers WE, et al. ACS Med Chem Lett. 2020 Mar 6;11(10):1820-1828. doi: 10.1021/acsmedchemlett.0c00006. eCollection 2020 Oct 8. ACS Med Chem Lett. 2020. PMID: 33062159 Free PMC article.

8

A novel assay platform for the detection of translation modulators of spermidine/spermine acetyltransferase.

Perez-Leal O, Abou-Gharbia M, Gordon J, Childers WE, Merali S. Perez-Leal O, et al. Curr Pharm Des. 2014;20(2):245-52. doi: 10.2174/13816128113199990035. Curr Pharm Des. 2014. PMID: 23701549 Free PMC article.

9

Essential roles of Leu/Ile/Phe-rich domain of JC virus agnoprotein in dimer/oligomer formation, protein stability and splicing of viral transcripts.

Sami Saribas A, Abou-Gharbia M, Childers W, Sariyer IK, White MK, Safak M. Sami Saribas A, et al. Virology. 2013 Aug 15;443(1):161-76. doi: 10.1016/j.virol.2013.05.003. Epub 2013 Jun 6. Virology. 2013. PMID: 23747198 Free PMC article.

10

Discovery of Novel Small-Molecule Inhibitors of SARS-CoV-2 Main Protease as Potential Leads for COVID-19 Treatment.

Manandhar A, Srinivasulu V, Hamad M, Tarazi H, Omar H, Colussi DJ, Gordon J, Childers W, Klein ML, Al-Tel TH, Abou-Gharbia M, Elokely KM. Manandhar A, et al. Among authors: abou gharbia m. J Chem Inf Model. 2021 Sep 27;61(9):4745-4757. doi: 10.1021/acs.jcim.1c00684. Epub 2021 Aug 17. J Chem Inf Model. 2021. PMID: 34403259

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