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Page 1
Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension.
Masson B, Le Ribeuz H, Sabourin J, Laubry L, Woodhouse E, Foster R, Ruchon Y, Dutheil M, Boët A, Ghigna MR, De Montpreville VT, Mercier O, Beech DJ, Benitah JP, Bailey MA, Humbert M, Montani D, Capuano V, Antigny F. Masson B, et al. Among authors: beech dj. Circ Res. 2022 Oct 14;131(9):e102-e119. doi: 10.1161/CIRCRESAHA.122.321041. Epub 2022 Sep 27. Circ Res. 2022. PMID: 36164973 Free article.
Upregulated TRPC1 channel in vascular injury in vivo and its role in human neointimal hyperplasia.
Kumar B, Dreja K, Shah SS, Cheong A, Xu SZ, Sukumar P, Naylor J, Forte A, Cipollaro M, McHugh D, Kingston PA, Heagerty AM, Munsch CM, Bergdahl A, Hultgårdh-Nilsson A, Gomez MF, Porter KE, Hellstrand P, Beech DJ. Kumar B, et al. Among authors: beech dj. Circ Res. 2006 Mar 3;98(4):557-63. doi: 10.1161/01.RES.0000204724.29685.db. Epub 2006 Jan 26. Circ Res. 2006. PMID: 16439693 Free PMC article.
Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction.
Naylor J, Li J, Milligan CJ, Zeng F, Sukumar P, Hou B, Sedo A, Yuldasheva N, Majeed Y, Beri D, Jiang S, Seymour VA, McKeown L, Kumar B, Harteneck C, O'Regan D, Wheatcroft SB, Kearney MT, Jones C, Porter KE, Beech DJ. Naylor J, et al. Among authors: beech dj. Circ Res. 2010 May 14;106(9):1507-15. doi: 10.1161/CIRCRESAHA.110.219329. Epub 2010 Apr 1. Circ Res. 2010. PMID: 20360246 Free PMC article.
Platelet-derived growth factor maintains stored calcium through a nonclustering Orai1 mechanism but evokes clustering if the endoplasmic reticulum is stressed by store depletion.
McKeown L, Moss NK, Turner P, Li J, Heath N, Burke D, O'Regan D, Gilthorpe MS, Porter KE, Beech DJ. McKeown L, et al. Among authors: beech dj. Circ Res. 2012 Jun 22;111(1):66-76. doi: 10.1161/CIRCRESAHA.111.263616. Epub 2012 May 3. Circ Res. 2012. PMID: 22556336 Free PMC article.
Orai3 Surface Accumulation and Calcium Entry Evoked by Vascular Endothelial Growth Factor.
Li J, Bruns AF, Hou B, Rode B, Webster PJ, Bailey MA, Appleby HL, Moss NK, Ritchie JE, Yuldasheva NY, Tumova S, Quinney M, McKeown L, Taylor H, Prasad KR, Burke D, O'Regan D, Porter KE, Foster R, Kearney MT, Beech DJ. Li J, et al. Among authors: beech dj. Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):1987-94. doi: 10.1161/ATVBAHA.115.305969. Epub 2015 Jul 9. Arterioscler Thromb Vasc Biol. 2015. PMID: 26160956 Free PMC article.
Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels.
Rubaiy HN, Ludlow MJ, Henrot M, Gaunt HJ, Miteva K, Cheung SY, Tanahashi Y, Hamzah N, Musialowski KE, Blythe NM, Appleby HL, Bailey MA, McKeown L, Taylor R, Foster R, Waldmann H, Nussbaumer P, Christmann M, Bon RS, Muraki K, Beech DJ. Rubaiy HN, et al. Among authors: beech dj. J Biol Chem. 2017 May 19;292(20):8158-8173. doi: 10.1074/jbc.M116.773556. Epub 2017 Mar 21. J Biol Chem. 2017. PMID: 28325835 Free PMC article.
Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance.
Rode B, Shi J, Endesh N, Drinkhill MJ, Webster PJ, Lotteau SJ, Bailey MA, Yuldasheva NY, Ludlow MJ, Cubbon RM, Li J, Futers TS, Morley L, Gaunt HJ, Marszalek K, Viswambharan H, Cuthbertson K, Baxter PD, Foster R, Sukumar P, Weightman A, Calaghan SC, Wheatcroft SB, Kearney MT, Beech DJ. Rode B, et al. Among authors: beech dj. Nat Commun. 2017 Aug 24;8(1):350. doi: 10.1038/s41467-017-00429-3. Nat Commun. 2017. PMID: 28839146 Free PMC article.
256 results