Chua NK - Search Results

1

Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin.

Ho GY, Kyran EL, Bedo J, Wakefield MJ, Ennis DP, Mirza HB, Vandenberg CJ, Lieschke E, Farrell A, Hadla A, Lim R, Dall G, Vince JE, Chua NK, Kondrashova O, Upstill-Goddard R, Bailey UM, Dowson S, Roxburgh P, Glasspool RM, Bryson G, Biankin AV; Scottish Genomes Partnership; Cooke SL, Ratnayake G, McNally O, Traficante N; Australian Ovarian Cancer Study12,13; DeFazio A, Weroha SJ, Bowtell DD, McNeish IA, Papenfuss AT, Scott CL, Barker HE. Ho GY, et al. Among authors: chua nk. Cancer Res. 2022 Dec 2;82(23):4457-4473. doi: 10.1158/0008-5472.CAN-21-4012. Cancer Res. 2022. PMID: 36206301 Free PMC article.

2

Lipid sensing tips the balance for a key cholesterol synthesis enzyme.

Chua NK, Brown AJ. Chua NK, et al. J Lipid Res. 2020 Nov;61(11):1363. doi: 10.1194/jlr.ILR120000801. Epub 2020 May 5. J Lipid Res. 2020. PMID: 32371565 Free PMC article. No abstract available.

3

A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis.

Chua NK, Howe V, Jatana N, Thukral L, Brown AJ. Chua NK, et al. J Biol Chem. 2017 Dec 8;292(49):19959-19973. doi: 10.1074/jbc.M117.794230. Epub 2017 Sep 27. J Biol Chem. 2017. PMID: 28972164 Free PMC article.

4

Non-canonical ubiquitination of the cholesterol-regulated degron of squalene monooxygenase.

Chua NK, Hart-Smith G, Brown AJ. Chua NK, et al. J Biol Chem. 2019 May 17;294(20):8134-8147. doi: 10.1074/jbc.RA119.007798. Epub 2019 Apr 2. J Biol Chem. 2019. PMID: 30940729 Free PMC article.

5

Valosin-containing protein mediates the ERAD of squalene monooxygenase and its cholesterol-responsive degron.

Chua NK, Scott NA, Brown AJ. Chua NK, et al. Biochem J. 2019 Sep 20;476(18):2545-2560. doi: 10.1042/BCJ20190418. Biochem J. 2019. PMID: 31471528

6

A key mammalian cholesterol synthesis enzyme, squalene monooxygenase, is allosterically stabilized by its substrate.

Yoshioka H, Coates HW, Chua NK, Hashimoto Y, Brown AJ, Ohgane K. Yoshioka H, et al. Among authors: chua nk. Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7150-7158. doi: 10.1073/pnas.1915923117. Epub 2020 Mar 13. Proc Natl Acad Sci U S A. 2020. PMID: 32170014 Free PMC article.

7

Squalene monooxygenase: a journey to the heart of cholesterol synthesis.

Chua NK, Coates HW, Brown AJ. Chua NK, et al. Prog Lipid Res. 2020 Jul;79:101033. doi: 10.1016/j.plipres.2020.101033. Epub 2020 Apr 28. Prog Lipid Res. 2020. PMID: 32360125 Review.

8

The Degron Architecture of Squalene Monooxygenase and How Specific Lipids Calibrate Levels of This Key Cholesterol Synthesis Enzyme.

Chua NK, Brown AJ. Chua NK, et al. Adv Exp Med Biol. 2021;21:1-12. doi: 10.1007/5584_2020_583. Adv Exp Med Biol. 2021. PMID: 32979157

9

The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change.

Howe V, Chua NK, Stevenson J, Brown AJ. Howe V, et al. Among authors: chua nk. J Biol Chem. 2015 Nov 13;290(46):27533-44. doi: 10.1074/jbc.M115.675181. Epub 2015 Oct 3. J Biol Chem. 2015. PMID: 26434806 Free PMC article.

10

Cholesterol homeostasis: How do cells sense sterol excess?

Howe V, Sharpe LJ, Alexopoulos SJ, Kunze SV, Chua NK, Li D, Brown AJ. Howe V, et al. Among authors: chua nk. Chem Phys Lipids. 2016 Sep;199:170-178. doi: 10.1016/j.chemphyslip.2016.02.011. Epub 2016 Mar 15. Chem Phys Lipids. 2016. PMID: 26993747 Review.

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