Adams JM - Search Results

1

Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia.

Moujalled DM, Brown FC, Chua CC, Dengler MA, Pomilio G, Anstee NS, Litalien V, Thompson E, Morley T, MacRaild S, Tiong IS, Morris R, Dun K, Zordan A, Shah J, Banquet S, Halilovic E, Morris E, Herold MJ, Lessene G, Adams JM, Huang DCS, Roberts AW, Blombery P, Wei AH. Moujalled DM, et al. Among authors: adams jm. Blood. 2023 Feb 9;141(6):634-644. doi: 10.1182/blood.2022016090. Blood. 2023. PMID: 36219880 Free PMC article.

2

Clonal hematopoiesis, myeloid disorders and BAX-mutated myelopoiesis in patients receiving venetoclax for CLL.

Blombery P, Lew TE, Dengler MA, Thompson ER, Lin VS, Chen X, Nguyen T, Panigrahi A, Handunnetti SM, Carney DA, Westerman DA, Tam CS, Adams JM, Wei AH, Huang DCS, Seymour JF, Roberts AW, Anderson MA. Blombery P, et al. Among authors: adams jm. Blood. 2022 Feb 24;139(8):1198-1207. doi: 10.1182/blood.2021012775. Blood. 2022. PMID: 34469514 Free PMC article. Clinical Trial.

3

BAX mitochondrial integration is regulated allosterically by its α1-α2 loop.

Dengler MA, Gibson L, Adams JM. Dengler MA, et al. Among authors: adams jm. Cell Death Differ. 2021 Dec;28(12):3270-3281. doi: 10.1038/s41418-021-00815-x. Epub 2021 Jun 16. Cell Death Differ. 2021. PMID: 34135480 Free PMC article.

4

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

van Delft MF, Wei AH, Mason KD, Vandenberg CJ, Chen L, Czabotar PE, Willis SN, Scott CL, Day CL, Cory S, Adams JM, Roberts AW, Huang DC. van Delft MF, et al. Among authors: adams jm. Cancer Cell. 2006 Nov;10(5):389-99. doi: 10.1016/j.ccr.2006.08.027. Cancer Cell. 2006. PMID: 17097561 Free PMC article.

5

Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma.

Dengler MA, Teh CE, Thijssen R, Gangoda L, Lan P, Herold MJ, Gray DH, Kelly GL, Roberts AW, Adams JM. Dengler MA, et al. Among authors: adams jm. Oncogene. 2020 Feb;39(9):2009-2023. doi: 10.1038/s41388-019-1122-x. Epub 2019 Nov 26. Oncogene. 2020. PMID: 31772331

6

Targeting BCL-2-like Proteins to Kill Cancer Cells.

Cory S, Roberts AW, Colman PM, Adams JM. Cory S, et al. Among authors: adams jm. Trends Cancer. 2016 Aug;2(8):443-460. doi: 10.1016/j.trecan.2016.07.001. Epub 2016 Jul 30. Trends Cancer. 2016. PMID: 28741496 Review.

7

BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association.

Dengler MA, Robin AY, Gibson L, Li MX, Sandow JJ, Iyer S, Webb AI, Westphal D, Dewson G, Adams JM. Dengler MA, et al. Among authors: adams jm. Cell Rep. 2019 Apr 9;27(2):359-373.e6. doi: 10.1016/j.celrep.2019.03.040. Cell Rep. 2019. PMID: 30970242 Free article.

8

Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target.

Iyer S, Uren RT, Dengler MA, Shi MX, Uno E, Adams JM, Dewson G, Kluck RM. Iyer S, et al. Among authors: adams jm. Cell Death Dis. 2020 Apr 23;11(4):268. doi: 10.1038/s41419-020-2463-7. Cell Death Dis. 2020. PMID: 32327636 Free PMC article.

9

The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4.

Huang DC, Adams JM, Cory S. Huang DC, et al. Among authors: adams jm. EMBO J. 1998 Feb 16;17(4):1029-39. doi: 10.1093/emboj/17.4.1029. EMBO J. 1998. PMID: 9463381 Free PMC article.

10

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC. Willis SN, et al. Among authors: adams jm. Genes Dev. 2005 Jun 1;19(11):1294-305. doi: 10.1101/gad.1304105. Epub 2005 May 18. Genes Dev. 2005. PMID: 15901672 Free PMC article.

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