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A network-based approach to quantifying the impact of biologically active substances.
Hoeng J, Deehan R, Pratt D, Martin F, Sewer A, Thomson TM, Drubin DA, Waters CA, de Graaf D, Peitsch MC. Hoeng J, et al. Among authors: peitsch mc. Drug Discov Today. 2012 May;17(9-10):413-8. doi: 10.1016/j.drudis.2011.11.008. Epub 2011 Dec 2. Drug Discov Today. 2012. PMID: 22155224 No abstract available.
Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers.
Mathis C, Poussin C, Weisensee D, Gebel S, Hengstermann A, Sewer A, Belcastro V, Xiang Y, Ansari S, Wagner S, Hoeng J, Peitsch MC. Mathis C, et al. Among authors: peitsch mc. Am J Physiol Lung Cell Mol Physiol. 2013 Apr 1;304(7):L489-503. doi: 10.1152/ajplung.00181.2012. Epub 2013 Jan 25. Am J Physiol Lung Cell Mol Physiol. 2013. PMID: 23355383 Free PMC article.
Cigarette-smoke-induced atherogenic lipid profiles in plasma and vascular tissue of apolipoprotein E-deficient mice are attenuated by smoking cessation.
Lietz M, Berges A, Lebrun S, Meurrens K, Steffen Y, Stolle K, Schueller J, Boue S, Vuillaume G, Vanscheeuwijck P, Moehring M, Schlage W, De Leon H, Hoeng J, Peitsch M. Lietz M, et al. Atherosclerosis. 2013 Jul;229(1):86-93. doi: 10.1016/j.atherosclerosis.2013.03.036. Epub 2013 Apr 22. Atherosclerosis. 2013. PMID: 23669247 Free article.
Systematic verification of upstream regulators of a computable cellular proliferation network model on non-diseased lung cells using a dedicated dataset.
Belcastro V, Poussin C, Gebel S, Mathis C, Schlage WK, Lichtner RB, Quadt-Humme S, Wagner S, Hoeng J, Peitsch MC. Belcastro V, et al. Among authors: peitsch mc. Bioinform Biol Insights. 2013 Jul 23;7:217-30. doi: 10.4137/BBI.S12167. Print 2013. Bioinform Biol Insights. 2013. PMID: 23926424 Free PMC article.
Case study: the role of mechanistic network models in systems toxicology.
Hoeng J, Talikka M, Martin F, Sewer A, Yang X, Iskandar A, Schlage WK, Peitsch MC. Hoeng J, et al. Among authors: peitsch mc. Drug Discov Today. 2014 Feb;19(2):183-92. doi: 10.1016/j.drudis.2013.07.023. Epub 2013 Aug 9. Drug Discov Today. 2014. PMID: 23933191 Review.
283 results