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Parallel detection of SARS-CoV-2 epitopes reveals dynamic immunodominance profiles of CD8+ T memory cells in convalescent COVID-19 donors.
van den Dijssel J, Hagen RR, de Jongh R, Steenhuis M, Rispens T, Geerdes DM, Mok JY, Kragten AH, Duurland MC, Verstegen NJ, van Ham SM, van Esch WJ, van Gisbergen KP, Hombrink P, Ten Brinke A, van de Sandt CE. van den Dijssel J, et al. Among authors: hombrink p. Clin Transl Immunology. 2022 Oct 14;11(10):e1423. doi: 10.1002/cti2.1423. eCollection 2022. Clin Transl Immunology. 2022. PMID: 36254196 Free PMC article.
Infection history determines the differentiation state of human CD8+ T cells.
van Aalderen MC, Remmerswaal EB, Verstegen NJ, Hombrink P, ten Brinke A, Pircher H, Kootstra NA, ten Berge IJ, van Lier RA. van Aalderen MC, et al. Among authors: hombrink p. J Virol. 2015 May;89(9):5110-23. doi: 10.1128/JVI.03478-14. Epub 2015 Feb 25. J Virol. 2015. PMID: 25717102 Free PMC article.
The Transcription Factor Hobit Identifies Human Cytotoxic CD4+ T Cells.
Oja AE, Vieira Braga FA, Remmerswaal EB, Kragten NA, Hertoghs KM, Zuo J, Moss PA, van Lier RA, van Gisbergen KP, Hombrink P. Oja AE, et al. Among authors: hombrink p. Front Immunol. 2017 Mar 24;8:325. doi: 10.3389/fimmu.2017.00325. eCollection 2017. Front Immunol. 2017. PMID: 28392788 Free PMC article.
Blimp-1 induces and Hobit maintains the cytotoxic mediator granzyme B in CD8 T cells.
Kragten NAM, Behr FM, Vieira Braga FA, Remmerswaal EBM, Wesselink TH, Oja AE, Hombrink P, Kallies A, van Lier RAW, Stark R, van Gisbergen KPJM. Kragten NAM, et al. Among authors: hombrink p. Eur J Immunol. 2018 Oct;48(10):1644-1662. doi: 10.1002/eji.201847771. Epub 2018 Aug 16. Eur J Immunol. 2018. PMID: 30051906 Free article.
Peripheral and systemic antigens elicit an expandable pool of resident memory CD8+ T cells in the bone marrow.
Pascutti MF, Geerman S, Collins N, Brasser G, Nota B, Stark R, Behr F, Oja A, Slot E, Panagioti E, Prier JE, Hickson S, Wolkers MC, Heemskerk MHM, Hombrink P, Arens R, Mackay LK, van Gisbergen KPJM, Nolte MA. Pascutti MF, et al. Among authors: hombrink p. Eur J Immunol. 2019 Jun;49(6):853-872. doi: 10.1002/eji.201848003. Epub 2019 Apr 2. Eur J Immunol. 2019. PMID: 30891737 Free PMC article.
Divergent SARS-CoV-2-specific T- and B-cell responses in severe but not mild COVID-19 patients.
Oja AE, Saris A, Ghandour CA, Kragten NAM, Hogema BM, Nossent EJ, Heunks LMA, Cuvalay S, Slot E, Linty F, Swaneveld FH, Vrielink H, Vidarsson G, Rispens T, van der Schoot E, van Lier RAW, Ten Brinke A, Hombrink P. Oja AE, et al. Among authors: hombrink p. Eur J Immunol. 2020 Dec;50(12):1998-2012. doi: 10.1002/eji.202048908. Epub 2020 Nov 16. Eur J Immunol. 2020. PMID: 33073359 Free article. Clinical Trial.
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