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Enhanced delivery of antibodies across the blood-brain barrier via TEMs with inherent receptor-mediated phagocytosis.
Edavettal S, Cejudo-Martin P, Dasgupta B, Yang D, Buschman MD, Domingo D, Van Kolen K, Jaiprasat P, Gordon R, Schutsky K, Geist B, Taylor N, Soubrane CH, Van Der Helm E, LaCombe A, Ainekulu Z, Lacy E, Aligo J, Ho J, He Y, Lebowitz PF, Patterson JT, Scheer JM, Singh S. Edavettal S, et al. Med. 2022 Dec 9;3(12):860-882.e15. doi: 10.1016/j.medj.2022.09.007. Epub 2022 Oct 17. Med. 2022. PMID: 36257298 Free article.
A T-cell-redirecting bispecific G-protein-coupled receptor class 5 member D x CD3 antibody to treat multiple myeloma.
Pillarisetti K, Edavettal S, Mendonça M, Li Y, Tornetta M, Babich A, Majewski N, Husovsky M, Reeves D, Walsh E, Chin D, Luistro L, Joseph J, Chu G, Packman K, Shetty S, Elsayed Y, Attar R, Gaudet F. Pillarisetti K, et al. Among authors: edavettal s. Blood. 2020 Apr 9;135(15):1232-1243. doi: 10.1182/blood.2019003342. Blood. 2020. PMID: 32040549 Free PMC article. Clinical Trial.
Design, synthesis and preclinical evaluation of bio-conjugated amylinomimetic peptides as long-acting amylin receptor agonists.
Patch RJ, Zhang R, Edavettal S, Macielag MJ, Eckardt AJ, Li J, Rives ML, Edwards W, Hinke SA, Qiu X, Jian W, Libiger O, Zheng S, Jeyaseelan J, Liang Y, Rangwala SM, Leonard JN, Hornby P. Patch RJ, et al. Among authors: edavettal s. Eur J Med Chem. 2022 Jun 5;236:114330. doi: 10.1016/j.ejmech.2022.114330. Epub 2022 Apr 4. Eur J Med Chem. 2022. PMID: 35436670
Conjugation of a peptide to an antibody engineered with free cysteines dramatically improves half-life and activity.
Camacho RC, You S, D'Aquino KE, Li W, Wang Y, Gunnet J, Littrell J, Qi JS, Kang L, Jian W, MacDonald M, Tat T, Steiner D, Zhang YM, Lanter J, Patch R, Zhang R, Li J, Edavettal S, Edwards W, Dinh T, Wang LY, Connor J, Hunter M, Chi E, Swanson RV, Leonard JN, Case MA. Camacho RC, et al. Among authors: edavettal s. MAbs. 2020 Jan-Dec;12(1):1794687. doi: 10.1080/19420862.2020.1794687. MAbs. 2020. PMID: 32744157 Free PMC article.
SUMO fusion technology for difficult-to-express proteins.
Butt TR, Edavettal SC, Hall JP, Mattern MR. Butt TR, et al. Protein Expr Purif. 2005 Sep;43(1):1-9. doi: 10.1016/j.pep.2005.03.016. Epub 2005 Apr 9. Protein Expr Purif. 2005. PMID: 16084395 Free PMC article. Review.
Recent advances in generative biology for biotherapeutic discovery.
Mock M, Langmead CJ, Grandsard P, Edavettal S, Russell A. Mock M, et al. Among authors: edavettal s. Trends Pharmacol Sci. 2024 Mar;45(3):255-267. doi: 10.1016/j.tips.2024.01.003. Epub 2024 Feb 19. Trends Pharmacol Sci. 2024. PMID: 38378385 Free article. Review.
Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties.
Sloman DL, Noucti N, Altman MD, Chen D, Mislak AC, Szewczak A, Hayashi M, Warren L, Dellovade T, Wu Z, Marcus J, Walker D, Su HP, Edavettal SC, Munshi S, Hutton M, Nuthall H, Stanton MG. Sloman DL, et al. Among authors: edavettal sc. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4362-6. doi: 10.1016/j.bmcl.2016.02.003. Epub 2016 Feb 6. Bioorg Med Chem Lett. 2016. PMID: 27491711
Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.
Tokarski JS, Zupa-Fernandez A, Tredup JA, Pike K, Chang C, Xie D, Cheng L, Pedicord D, Muckelbauer J, Johnson SR, Wu S, Edavettal SC, Hong Y, Witmer MR, Elkin LL, Blat Y, Pitts WJ, Weinstein DS, Burke JR. Tokarski JS, et al. Among authors: edavettal sc. J Biol Chem. 2015 Apr 24;290(17):11061-74. doi: 10.1074/jbc.M114.619502. Epub 2015 Mar 11. J Biol Chem. 2015. PMID: 25762719 Free PMC article.
16 results