Karcz TP - Search Results

1

Effects of Purinergic Receptor Deletion or Pharmacologic Modulation on Pulmonary Inflammation in Mice.

Whitehead GS, Karcz TP, Tosh DK, Jung YH, Wen Z, Campbell RG, Gopinatth V, Gao ZG, Jacobson KA, Cook DN. Whitehead GS, et al. Among authors: karcz tp. ACS Pharmacol Transl Sci. 2022 Oct 5;5(10):973-984. doi: 10.1021/acsptsci.2c00128. eCollection 2022 Oct 14. ACS Pharmacol Transl Sci. 2022. PMID: 36268115 Free PMC article.

2

Therapeutic suppression of pulmonary neutrophilia and allergic airway hyperresponsiveness by a RORγt inverse agonist.

Whitehead GS, Kang HS, Thomas SY, Medvedev A, Karcz TP, Izumi G, Nakano K, Makarov SS, Nakano H, Jetten AM, Cook DN. Whitehead GS, et al. Among authors: karcz tp. JCI Insight. 2019 Jun 11;5(14):e125528. doi: 10.1172/jci.insight.125528. JCI Insight. 2019. PMID: 31184998 Free PMC article.

3

Exploration of Alternative Scaffolds for P2Y₁₄ Receptor Antagonists Containing a Biaryl Core.

Jung YH, Yu J, Wen Z, Salmaso V, Karcz TP, Phung NB, Chen Z, Duca S, Bennett JM, Dudas S, Salvemini D, Gao ZG, Cook DN, Jacobson KA. Jung YH, et al. Among authors: karcz tp. J Med Chem. 2020 Sep 10;63(17):9563-9589. doi: 10.1021/acs.jmedchem.0c00745. Epub 2020 Aug 6. J Med Chem. 2020. PMID: 32787142 Free PMC article.

4

Structure-Activity Relationship of Heterocyclic P2Y₁₄ Receptor Antagonists: Removal of the Zwitterionic Character with Piperidine Bioisosteres.

Jung YH, Salmaso V, Wen Z, Bennett JM, Phung NB, Lieberman DI, Gopinatth V, Randle JCR, Chen Z, Salvemini D, Karcz TP, Cook DN, Jacobson KA. Jung YH, et al. Among authors: karcz tp. J Med Chem. 2021 Apr 22;64(8):5099-5122. doi: 10.1021/acs.jmedchem.1c00164. Epub 2021 Mar 31. J Med Chem. 2021. PMID: 33787273 Free PMC article.

5

UDP-glucose and P2Y14 receptor amplify allergen-induced airway eosinophilia.

Karcz TP, Whitehead GS, Nakano K, Nakano H, Grimm SA, Williams JG, Deterding LJ, Jacobson KA, Cook DN. Karcz TP, et al. J Clin Invest. 2021 Apr 1;131(7):e140709. doi: 10.1172/JCI140709. J Clin Invest. 2021. PMID: 33792561 Free PMC article.

6

Adipocyte P2Y14 receptors play a key role in regulating whole-body glucose and lipid homeostasis.

Jain S, Pydi SP, Jung YH, Scortichini M, Kesner EL, Karcz TP, Cook DN, Gavrilova O, Wess J, Jacobson KA. Jain S, et al. Among authors: karcz tp. JCI Insight. 2021 May 24;6(10):e146577. doi: 10.1172/jci.insight.146577. JCI Insight. 2021. PMID: 34027896 Free PMC article.

7

Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2Y₁₄R Antagonist.

Wen Z, Salmaso V, Jung YH, Phung NB, Gopinatth V, Shah Q, Patterson AT, Randle JCR, Chen Z, Salvemini D, Lieberman DI, Whitehead GS, Karcz TP, Cook DN, Jacobson KA. Wen Z, et al. Among authors: karcz tp. J Med Chem. 2022 Feb 24;65(4):3434-3459. doi: 10.1021/acs.jmedchem.1c01964. Epub 2022 Feb 3. J Med Chem. 2022. PMID: 35113556 Free PMC article.

8

Synthesis and biological activity of tricyclic cycloalkylimidazo-, pyrimido- and diazepinopurinediones.

Drabczyńska A, Yuzlenko O, Köse M, Paskaleva M, Schiedel AC, Karolak-Wojciechowska J, Handzlik J, Karcz T, Kuder K, Müller CE, Kieć-Kononowicz K. Drabczyńska A, et al. Eur J Med Chem. 2011 Sep;46(9):3590-607. doi: 10.1016/j.ejmech.2011.05.023. Epub 2011 May 23. Eur J Med Chem. 2011. PMID: 21664729

9

7-Alkyl-3-benzylcoumarins: a versatile scaffold for the development of potent and selective cannabinoid receptor agonists and antagonists.

Rempel V, Volz N, Hinz S, Karcz T, Meliciani I, Nieger M, Wenzel W, Bräse S, Müller CE. Rempel V, et al. J Med Chem. 2012 Sep 27;55(18):7967-77. doi: 10.1021/jm3008213. Epub 2012 Sep 11. J Med Chem. 2012. PMID: 22916707

10

Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands.

Łażewska D, Więcek M, Ner J, Kamińska K, Kottke T, Schwed JS, Zygmunt M, Karcz T, Olejarz A, Kuder K, Latacz G, Grosicki M, Sapa J, Karolak-Wojciechowska J, Stark H, Kieć-Kononowicz K. Łażewska D, et al. Eur J Med Chem. 2014 Aug 18;83:534-46. doi: 10.1016/j.ejmech.2014.06.032. Epub 2014 Jun 17. Eur J Med Chem. 2014. PMID: 24996140

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