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Page 1
A mechanistic framework for cardiometabolic and coronary artery diseases.
Koplev S, Seldin M, Sukhavasi K, Ermel R, Pang S, Zeng L, Bankier S, Di Narzo A, Cheng H, Meda V, Ma A, Talukdar H, Cohain A, Amadori L, Argmann C, Houten SM, Franzén O, Mocci G, Meelu OA, Ishikawa K, Whatling C, Jain A, Jain RK, Gan LM, Giannarelli C, Roussos P, Hao K, Schunkert H, Michoel T, Ruusalepp A, Schadt EE, Kovacic JC, Lusis AJ, Björkegren JLM. Koplev S, et al. Among authors: cohain a. Nat Cardiovasc Res. 2022 Jan;1(1):85-100. doi: 10.1038/s44161-021-00009-1. Epub 2022 Jan 12. Nat Cardiovasc Res. 2022. PMID: 36276926 Free PMC article.
Assembly and diploid architecture of an individual human genome via single-molecule technologies.
Pendleton M, Sebra R, Pang AW, Ummat A, Franzen O, Rausch T, Stütz AM, Stedman W, Anantharaman T, Hastie A, Dai H, Fritz MH, Cao H, Cohain A, Deikus G, Durrett RE, Blanchard SC, Altman R, Chin CS, Guo Y, Paxinos EE, Korbel JO, Darnell RB, McCombie WR, Kwok PY, Mason CE, Schadt EE, Bashir A. Pendleton M, et al. Among authors: cohain a. Nat Methods. 2015 Aug;12(8):780-6. doi: 10.1038/nmeth.3454. Epub 2015 Jun 29. Nat Methods. 2015. PMID: 26121404 Free PMC article.
Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability.
Evrard SM, Lecce L, Michelis KC, Nomura-Kitabayashi A, Pandey G, Purushothaman KR, d'Escamard V, Li JR, Hadri L, Fujitani K, Moreno PR, Benard L, Rimmele P, Cohain A, Mecham B, Randolph GJ, Nabel EG, Hajjar R, Fuster V, Boehm M, Kovacic JC. Evrard SM, et al. Among authors: cohain a. Nat Commun. 2016 Jun 24;7:11853. doi: 10.1038/ncomms11853. Nat Commun. 2016. PMID: 27340017 Free PMC article.
Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci.
Miller CL, Pjanic M, Wang T, Nguyen T, Cohain A, Lee JD, Perisic L, Hedin U, Kundu RK, Majmudar D, Kim JB, Wang O, Betsholtz C, Ruusalepp A, Franzén O, Assimes TL, Montgomery SB, Schadt EE, Björkegren JLM, Quertermous T. Miller CL, et al. Among authors: cohain a. Nat Commun. 2016 Jul 8;7:12092. doi: 10.1038/ncomms12092. Nat Commun. 2016. PMID: 27386823 Free PMC article.
Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases.
Franzén O, Ermel R, Cohain A, Akers NK, Di Narzo A, Talukdar HA, Foroughi-Asl H, Giambartolomei C, Fullard JF, Sukhavasi K, Köks S, Gan LM, Giannarelli C, Kovacic JC, Betsholtz C, Losic B, Michoel T, Hao K, Roussos P, Skogsberg J, Ruusalepp A, Schadt EE, Björkegren JL. Franzén O, et al. Among authors: cohain a. Science. 2016 Aug 19;353(6301):827-30. doi: 10.1126/science.aad6970. Science. 2016. PMID: 27540175 Free PMC article.
Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach.
Mendelson MM, Marioni RE, Joehanes R, Liu C, Hedman ÅK, Aslibekyan S, Demerath EW, Guan W, Zhi D, Yao C, Huan T, Willinger C, Chen B, Courchesne P, Multhaup M, Irvin MR, Cohain A, Schadt EE, Grove ML, Bressler J, North K, Sundström J, Gustafsson S, Shah S, McRae AF, Harris SE, Gibson J, Redmond P, Corley J, Murphy L, Starr JM, Kleinbrink E, Lipovich L, Visscher PM, Wray NR, Krauss RM, Fallin D, Feinberg A, Absher DM, Fornage M, Pankow JS, Lind L, Fox C, Ingelsson E, Arnett DK, Boerwinkle E, Liang L, Levy D, Deary IJ. Mendelson MM, et al. Among authors: cohain a. PLoS Med. 2017 Jan 17;14(1):e1002215. doi: 10.1371/journal.pmed.1002215. eCollection 2017 Jan. PLoS Med. 2017. PMID: 28095459 Free PMC article.
Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.
Morgan RA, Beck KR, Nixon M, Homer NZM, Crawford AA, Melchers D, Houtman R, Meijer OC, Stomby A, Anderson AJ, Upreti R, Stimson RH, Olsson T, Michoel T, Cohain A, Ruusalepp A, Schadt EE, Björkegren JLM, Andrew R, Kenyon CJ, Hadoke PWF, Odermatt A, Keen JA, Walker BR. Morgan RA, et al. Among authors: cohain a. Sci Rep. 2017 Sep 6;7(1):10633. doi: 10.1038/s41598-017-10410-1. Sci Rep. 2017. PMID: 28878267 Free PMC article.
Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions.
Watson CT, Cohain AT, Griffin RS, Chun Y, Grishin A, Hacyznska H, Hoffman GE, Beckmann ND, Shah H, Dawson P, Henning A, Wood R, Burks AW, Jones SM, Leung DYM, Sicherer S, Sampson HA, Sharp AJ, Schadt EE, Bunyavanich S. Watson CT, et al. Among authors: cohain at. Nat Commun. 2017 Dec 5;8(1):1943. doi: 10.1038/s41467-017-02188-7. Nat Commun. 2017. PMID: 29203772 Free PMC article.
Differential activity of transcribed enhancers in the prefrontal cortex of 537 cases with schizophrenia and controls.
Hauberg ME, Fullard JF, Zhu L, Cohain AT, Giambartolomei C, Misir R, Reach S, Johnson JS, Wang M, Mattheisen M, Børglum AD, Zhang B, Sieberts SK, Peters MA, Domenici E, Schadt EE, Devlin B, Sklar P, Roeder K, Roussos P; CommonMind Consortium. Hauberg ME, et al. Among authors: cohain at. Mol Psychiatry. 2019 Nov;24(11):1685-1695. doi: 10.1038/s41380-018-0059-8. Epub 2018 May 8. Mol Psychiatry. 2019. PMID: 29740122 Free PMC article.
31 results