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Adaptive single-KIR+NKG2C+ NK cells expanded from select superdonors show potent missing-self reactivity and efficiently control HLA-mismatched acute myeloid leukemia.
Haroun-Izquierdo A, Vincenti M, Netskar H, van Ooijen H, Zhang B, Bendzick L, Kanaya M, Momayyezi P, Li S, Wiiger MT, Hoel HJ, Krokeide SZ, Kremer V, Tjonnfjord G, Berggren S, Wikström K, Blomberg P, Alici E, Felices M, Önfelt B, Höglund P, Valamehr B, Ljunggren HG, Björklund A, Hammer Q, Kveberg L, Cichocki F, Miller JS, Malmberg KJ, Sohlberg E. Haroun-Izquierdo A, et al. Among authors: onfelt b. J Immunother Cancer. 2022 Nov;10(11):e005577. doi: 10.1136/jitc-2022-005577. J Immunother Cancer. 2022. PMID: 36319065 Free PMC article.
Coordinated expression of DNAM-1 and LFA-1 in educated NK cells.
Enqvist M, Ask EH, Forslund E, Carlsten M, Abrahamsen G, Béziat V, Andersson S, Schaffer M, Spurkland A, Bryceson Y, Önfelt B, Malmberg KJ. Enqvist M, et al. Among authors: onfelt b. J Immunol. 2015 May 1;194(9):4518-27. doi: 10.4049/jimmunol.1401972. Epub 2015 Mar 30. J Immunol. 2015. PMID: 25825444
Microchip-Based Single-Cell Imaging Reveals That CD56dimCD57-KIR-NKG2A+ NK Cells Have More Dynamic Migration Associated with Increased Target Cell Conjugation and Probability of Killing Compared to CD56dimCD57-KIR-NKG2A- NK Cells.
Forslund E, Sohlberg E, Enqvist M, Olofsson PE, Malmberg KJ, Önfelt B. Forslund E, et al. Among authors: onfelt b. J Immunol. 2015 Oct 1;195(7):3374-81. doi: 10.4049/jimmunol.1500171. Epub 2015 Aug 28. J Immunol. 2015. PMID: 26320254
Intrinsic Functional Potential of NK-Cell Subsets Constrains Retargeting Driven by Chimeric Antigen Receptors.
Oei VYS, Siernicka M, Graczyk-Jarzynka A, Hoel HJ, Yang W, Palacios D, Almåsbak H, Bajor M, Clement D, Brandt L, Önfelt B, Goodridge J, Winiarska M, Zagozdzon R, Olweus J, Kyte JA, Malmberg KJ. Oei VYS, et al. Among authors: onfelt b. Cancer Immunol Res. 2018 Apr;6(4):467-480. doi: 10.1158/2326-6066.CIR-17-0207. Epub 2018 Feb 19. Cancer Immunol Res. 2018. PMID: 29459477
161533 TriKE stimulates NK-cell function to overcome myeloid-derived suppressor cells in MDS.
Sarhan D, Brandt L, Felices M, Guldevall K, Lenvik T, Hinderlie P, Curtsinger J, Warlick E, Spellman SR, Blazar BR, Weisdorf DJ, Cooley S, Vallera DA, Önfelt B, Miller JS. Sarhan D, et al. Among authors: onfelt b. Blood Adv. 2018 Jun 26;2(12):1459-1469. doi: 10.1182/bloodadvances.2017012369. Blood Adv. 2018. PMID: 29941459 Free PMC article.
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