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Superoxide production by NAD(P)H oxidase and mitochondria is increased in genetically obese and hyperglycemic rat heart and aorta before the development of cardiac dysfunction. The role of glucose-6-phosphate dehydrogenase-derived NADPH.
Serpillon S, Floyd BC, Gupte RS, George S, Kozicky M, Neito V, Recchia F, Stanley W, Wolin MS, Gupte SA. Serpillon S, et al. Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H153-62. doi: 10.1152/ajpheart.01142.2008. Epub 2009 May 8. Am J Physiol Heart Circ Physiol. 2009. PMID: 19429815 Free PMC article.
Glucose-6-phosphate dehydrogenase plays a critical role in hypoxia-induced CD133+ progenitor cells self-renewal and stimulates their accumulation in the lungs of pulmonary hypertensive rats.
Chettimada S, Joshi SR, Alzoubi A, Gebb SA, McMurtry IF, Gupte R, Gupte SA. Chettimada S, et al. Among authors: gupte sa, gupte r. Am J Physiol Lung Cell Mol Physiol. 2014 Oct 1;307(7):L545-56. doi: 10.1152/ajplung.00303.2013. Epub 2014 Jul 25. Am J Physiol Lung Cell Mol Physiol. 2014. PMID: 25063801 Free PMC article.
Increased reactive oxygen species, metabolic maladaptation, and autophagy contribute to pulmonary arterial hypertension-induced ventricular hypertrophy and diastolic heart failure.
Rawat DK, Alzoubi A, Gupte R, Chettimada S, Watanabe M, Kahn AG, Okada T, McMurtry IF, Gupte SA. Rawat DK, et al. Among authors: gupte sa, gupte r. Hypertension. 2014 Dec;64(6):1266-74. doi: 10.1161/HYPERTENSIONAHA.114.03261. Epub 2014 Sep 29. Hypertension. 2014. PMID: 25267798
71 results