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Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behavior.
Delbès AS, Quiñones M, Gobet C, Castel J, Denis RGP, Berthelet J, Weger BD, Challet E, Charpagne A, Metairon S, Piccand J, Kraus M, Rohde BH, Bial J, Wilson EM, Vedin LL, Minniti ME, Pedrelli M, Parini P, Gachon F, Luquet S. Delbès AS, et al. Among authors: berthelet j. Sci Adv. 2023 May 19;9(20):eadf2982. doi: 10.1126/sciadv.adf2982. Epub 2023 May 17. Sci Adv. 2023. PMID: 37196091 Free PMC article.
Benzoquinone, a leukemogenic metabolite of benzene, catalytically inhibits the protein tyrosine phosphatase PTPN2 and alters STAT1 signaling.
Duval R, Bui LC, Mathieu C, Nian Q, Berthelet J, Xu X, Haddad I, Vinh J, Dupret JM, Busi F, Guidez F, Chomienne C, Rodrigues-Lima F. Duval R, et al. Among authors: berthelet j. J Biol Chem. 2019 Aug 16;294(33):12483-12494. doi: 10.1074/jbc.RA119.008666. Epub 2019 Jun 27. J Biol Chem. 2019. PMID: 31248982 Free PMC article.
From transglutaminases (TGs) to arylamine N-acetyltransferases (NATs): Insight into the role of a spatially conserved aromatic amino acid position in the active site of these two families of enzymes.
Xu X, Zhang W, Berthelet J, Liu R, Michail C, Chaffotte AF, Dupret JM, Rodrigues-Lima F. Xu X, et al. Among authors: berthelet j. Biochem Biophys Res Commun. 2020 Apr 30;525(2):308-312. doi: 10.1016/j.bbrc.2020.02.082. Epub 2020 Feb 20. Biochem Biophys Res Commun. 2020. PMID: 32089267
Human CREBBP acetyltransferase is impaired by etoposide quinone, an oxidative and leukemogenic metabolite of the anticancer drug etoposide through modification of redox-sensitive zinc-finger cysteine residues.
Zhang W, Berthelet J, Michail C, Bui LC, Gou P, Liu R, Duval R, Renault J, Dupret JM, Guidez F, Chomienne C, Rodrigues Lima F. Zhang W, et al. Among authors: berthelet j. Free Radic Biol Med. 2021 Jan;162:27-37. doi: 10.1016/j.freeradbiomed.2020.11.027. Epub 2020 Dec 2. Free Radic Biol Med. 2021. PMID: 33278510
52 results