Hanke T - Search Results

1

Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.

Amrhein JA, Beyett TS, Feng WW, Krämer A, Weckesser J, Schaeffner IK, Rana JK, Jänne PA, Eck MJ, Knapp S, Hanke T. Amrhein JA, et al. Among authors: hanke t. J Med Chem. 2022 Dec 8;65(23):15679-15697. doi: 10.1021/acs.jmedchem.2c01041. Epub 2022 Nov 16. J Med Chem. 2022. PMID: 36384036 Free PMC article.

2

Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo.

Hanke T, Dehm F, Liening S, Popella SD, Maczewsky J, Pillong M, Kunze J, Weinigel C, Barz D, Kaiser A, Wurglics M, Lämmerhofer M, Schneider G, Sautebin L, Schubert-Zsilavecz M, Werz O. Hanke T, et al. J Med Chem. 2013 Nov 27;56(22):9031-44. doi: 10.1021/jm401557w. Epub 2013 Nov 15. J Med Chem. 2013. PMID: 24171493

3

Synthesis and pharmacological characterization of benzenesulfonamides as dual species inhibitors of human and murine mPGES-1.

Hanke T, Rörsch F, Thieme TM, Ferreiros N, Schneider G, Geisslinger G, Proschak E, Grösch S, Schubert-Zsilavecz M. Hanke T, et al. Bioorg Med Chem. 2013 Dec 15;21(24):7874-83. doi: 10.1016/j.bmc.2013.10.006. Epub 2013 Oct 16. Bioorg Med Chem. 2013. PMID: 24183739

4

Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome.

Kashima R, Redmond PL, Ghatpande P, Roy S, Kornberg TB, Hanke T, Knapp S, Lagna G, Hata A. Kashima R, et al. Among authors: hanke t. Sci Signal. 2017 May 2;10(477):eaai8133. doi: 10.1126/scisignal.aai8133. Sci Signal. 2017. PMID: 28465421 Free PMC article.

5

Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement.

Vasta JD, Corona CR, Wilkinson J, Zimprich CA, Hartnett JR, Ingold MR, Zimmerman K, Machleidt T, Kirkland TA, Huwiler KG, Ohana RF, Slater M, Otto P, Cong M, Wells CI, Berger BT, Hanke T, Glas C, Ding K, Drewry DH, Huber KVM, Willson TM, Knapp S, Müller S, Meisenheimer PL, Fan F, Wood KV, Robers MB. Vasta JD, et al. Among authors: hanke t. Cell Chem Biol. 2018 Feb 15;25(2):206-214.e11. doi: 10.1016/j.chembiol.2017.10.010. Epub 2017 Nov 22. Cell Chem Biol. 2018. PMID: 29174542 Free PMC article.

6

A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5.

Hanke T, Wong JF, Berger BT, Abdi I, Berger LM, Tesch R, Tredup C, Bullock AN, Müller S, Knapp S. Hanke T, et al. ACS Chem Biol. 2020 Apr 17;15(4):862-870. doi: 10.1021/acschembio.0c00076. Epub 2020 Mar 20. ACS Chem Biol. 2020. PMID: 32176847

7

A Selective Modulator of Peroxisome Proliferator-Activated Receptor γ with an Unprecedented Binding Mode.

Hanke T, Cheung SY, Kilu W, Heering J, Ni X, Planz V, Schierle S, Faudone G, Friedrich M, Wanior M, Werz O, Windbergs M, Proschak E, Schubert-Zsilavecz M, Chaikuad A, Knapp S, Merk D. Hanke T, et al. J Med Chem. 2020 May 14;63(9):4555-4561. doi: 10.1021/acs.jmedchem.9b01786. Epub 2020 Apr 20. J Med Chem. 2020. PMID: 32267688

8

Optimization of pyrazolo[1,5-a]pyrimidines lead to the identification of a highly selective casein kinase 2 inhibitor.

Krämer A, Kurz CG, Berger BT, Celik IE, Tjaden A, Greco FA, Knapp S, Hanke T. Krämer A, et al. Among authors: hanke t. Eur J Med Chem. 2020 Dec 15;208:112770. doi: 10.1016/j.ejmech.2020.112770. Epub 2020 Aug 23. Eur J Med Chem. 2020. PMID: 32883634

9

Synthetic Opportunities and Challenges for Macrocyclic Kinase Inhibitors.

Amrhein JA, Knapp S, Hanke T. Amrhein JA, et al. Among authors: hanke t. J Med Chem. 2021 Jun 24;64(12):7991-8009. doi: 10.1021/acs.jmedchem.1c00217. Epub 2021 Jun 2. J Med Chem. 2021. PMID: 34076436 Review.

10

Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors.

Tesch R, Rak M, Raab M, Berger LM, Kronenberger T, Joerger AC, Berger BT, Abdi I, Hanke T, Poso A, Strebhardt K, Sanhaji M, Knapp S. Tesch R, et al. Among authors: hanke t. J Med Chem. 2021 Jun 24;64(12):8142-8160. doi: 10.1021/acs.jmedchem.0c02144. Epub 2021 Jun 4. J Med Chem. 2021. PMID: 34086472

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