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IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network.
Schmacke NA, O'Duill F, Gaidt MM, Szymanska I, Kamper JM, Schmid-Burgk JL, Mädler SC, Mackens-Kiani T, Kozaki T, Chauhan D, Nagl D, Stafford CA, Harz H, Fröhlich AL, Pinci F, Ginhoux F, Beckmann R, Mann M, Leonhardt H, Hornung V. Schmacke NA, et al. Among authors: hornung v. Immunity. 2022 Dec 13;55(12):2271-2284.e7. doi: 10.1016/j.immuni.2022.10.021. Epub 2022 Nov 15. Immunity. 2022. PMID: 36384135 Free PMC article.
Inflammasomes: current understanding and open questions.
Bauernfeind F, Ablasser A, Bartok E, Kim S, Schmid-Burgk J, Cavlar T, Hornung V. Bauernfeind F, et al. Among authors: hornung v. Cell Mol Life Sci. 2011 Mar;68(5):765-83. doi: 10.1007/s00018-010-0567-4. Epub 2010 Oct 31. Cell Mol Life Sci. 2011. PMID: 21072676 Review.
NLRP3 inflammasome activity is negatively controlled by miR-223.
Bauernfeind F, Rieger A, Schildberg FA, Knolle PA, Schmid-Burgk JL, Hornung V. Bauernfeind F, et al. Among authors: hornung v. J Immunol. 2012 Oct 15;189(8):4175-81. doi: 10.4049/jimmunol.1201516. Epub 2012 Sep 14. J Immunol. 2012. PMID: 22984082
Cytosolic RNA:DNA hybrids activate the cGAS-STING axis.
Mankan AK, Schmidt T, Chauhan D, Goldeck M, Höning K, Gaidt M, Kubarenko AV, Andreeva L, Hopfner KP, Hornung V. Mankan AK, et al. Among authors: hornung v. EMBO J. 2014 Dec 17;33(24):2937-46. doi: 10.15252/embj.201488726. Epub 2014 Nov 25. EMBO J. 2014. PMID: 25425575 Free PMC article.
214 results