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Page 1
How Carvedilol activates β2-adrenoceptors.
Benkel T, Zimmermann M, Zeiner J, Bravo S, Merten N, Lim VJY, Matthees ESF, Drube J, Miess-Tanneberg E, Malan D, Szpakowska M, Monteleone S, Grimes J, Koszegi Z, Lanoiselée Y, O'Brien S, Pavlaki N, Dobberstein N, Inoue A, Nikolaev V, Calebiro D, Chevigné A, Sasse P, Schulz S, Hoffmann C, Kolb P, Waldhoer M, Simon K, Gomeza J, Kostenis E. Benkel T, et al. Nat Commun. 2022 Nov 19;13(1):7109. doi: 10.1038/s41467-022-34765-w. Nat Commun. 2022. PMID: 36402762 Free PMC article.
Lack of beta-arrestin signaling in the absence of active G proteins.
Grundmann M, Merten N, Malfacini D, Inoue A, Preis P, Simon K, Rüttiger N, Ziegler N, Benkel T, Schmitt NK, Ishida S, Müller I, Reher R, Kawakami K, Inoue A, Rick U, Kühl T, Imhof D, Aoki J, König GM, Hoffmann C, Gomeza J, Wess J, Kostenis E. Grundmann M, et al. Among authors: benkel t. Nat Commun. 2018 Jan 23;9(1):341. doi: 10.1038/s41467-017-02661-3. Nat Commun. 2018. PMID: 29362459 Free PMC article.
BIM-46174 fragments as potential ligands of G proteins.
Küppers J, Benkel T, Annala S, Schnakenburg G, Kostenis E, Gütschow M. Küppers J, et al. Among authors: benkel t. Medchemcomm. 2019 Aug 21;10(10):1838-1843. doi: 10.1039/c9md00269c. eCollection 2019 Oct 1. Medchemcomm. 2019. PMID: 32180917 Free PMC article.
Reply to: How carvedilol does not activate β2-adrenoceptors.
Kostenis E, Gomeza J, Miess-Tanneberg E, Blum NK, Benkel T, Chevigné A, Hoffmann C, Kolb P, Nikolaev V, Waldhoer M, Szpakowska M, Inoue A, Schulz S. Kostenis E, et al. Among authors: benkel t. Nat Commun. 2023 Nov 30;14(1):7867. doi: 10.1038/s41467-023-42849-4. Nat Commun. 2023. PMID: 38036502 Free PMC article. No abstract available.
Deciphering Specificity Determinants for FR900359-Derived Gq α Inhibitors Based on Computational and Structure-Activity Studies.
Reher R, Kühl T, Annala S, Benkel T, Kaufmann D, Nubbemeyer B, Odhiambo JP, Heimer P, Bäuml CA, Kehraus S, Crüsemann M, Kostenis E, Tietze D, König GM, Imhof D. Reher R, et al. Among authors: benkel t. ChemMedChem. 2018 Aug 20;13(16):1634-1643. doi: 10.1002/cmdc.201800304. Epub 2018 Jul 3. ChemMedChem. 2018. PMID: 29873888