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Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole-body homeostasis.
Zhang Q, Duplany A, Moncollin V, Mouradian S, Goillot E, Mazelin L, Gauthier K, Streichenberger N, Angleraux C, Chen J, Ding S, Schaeffer L, Gangloff YG. Zhang Q, et al. Among authors: gangloff yg. J Cachexia Sarcopenia Muscle. 2019 Feb;10(1):35-53. doi: 10.1002/jcsm.12336. Epub 2018 Nov 21. J Cachexia Sarcopenia Muscle. 2019. PMID: 30461220 Free PMC article.
Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy.
Risson V, Mazelin L, Roceri M, Sanchez H, Moncollin V, Corneloup C, Richard-Bulteau H, Vignaud A, Baas D, Defour A, Freyssenet D, Tanti JF, Le-Marchand-Brustel Y, Ferrier B, Conjard-Duplany A, Romanino K, Bauché S, Hantaï D, Mueller M, Kozma SC, Thomas G, Rüegg MA, Ferry A, Pende M, Bigard X, Koulmann N, Schaeffer L, Gangloff YG. Risson V, et al. Among authors: gangloff yg. J Cell Biol. 2009 Dec 14;187(6):859-74. doi: 10.1083/jcb.200903131. J Cell Biol. 2009. PMID: 20008564 Free PMC article.
mTOR inactivation in myocardium from infant mice rapidly leads to dilated cardiomyopathy due to translation defects and p53/JNK-mediated apoptosis.
Mazelin L, Panthu B, Nicot AS, Belotti E, Tintignac L, Teixeira G, Zhang Q, Risson V, Baas D, Delaune E, Derumeaux G, Taillandier D, Ohlmann T, Ovize M, Gangloff YG, Schaeffer L. Mazelin L, et al. Among authors: gangloff yg. J Mol Cell Cardiol. 2016 Aug;97:213-25. doi: 10.1016/j.yjmcc.2016.04.011. Epub 2016 Apr 28. J Mol Cell Cardiol. 2016. PMID: 27133769
Increased Serpina3n release into circulation during glucocorticoid-mediated muscle atrophy.
Gueugneau M, d'Hose D, Barbé C, de Barsy M, Lause P, Maiter D, Bindels LB, Delzenne NM, Schaeffer L, Gangloff YG, Chambon C, Coudy-Gandilhon C, Béchet D, Thissen JP. Gueugneau M, et al. Among authors: gangloff yg. J Cachexia Sarcopenia Muscle. 2018 Oct;9(5):929-946. doi: 10.1002/jcsm.12315. Epub 2018 Jul 10. J Cachexia Sarcopenia Muscle. 2018. PMID: 29989354 Free PMC article.
Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function.
Romanino K, Mazelin L, Albert V, Conjard-Duplany A, Lin S, Bentzinger CF, Handschin C, Puigserver P, Zorzato F, Schaeffer L, Gangloff YG, Rüegg MA. Romanino K, et al. Among authors: gangloff yg. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20808-13. doi: 10.1073/pnas.1111448109. Epub 2011 Dec 5. Proc Natl Acad Sci U S A. 2011. PMID: 22143799 Free PMC article.
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