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Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole-body homeostasis.
Zhang Q, Duplany A, Moncollin V, Mouradian S, Goillot E, Mazelin L, Gauthier K, Streichenberger N, Angleraux C, Chen J, Ding S, Schaeffer L, Gangloff YG. Zhang Q, et al. Among authors: mazelin l. J Cachexia Sarcopenia Muscle. 2019 Feb;10(1):35-53. doi: 10.1002/jcsm.12336. Epub 2018 Nov 21. J Cachexia Sarcopenia Muscle. 2019. PMID: 30461220 Free PMC article.
Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy.
Risson V, Mazelin L, Roceri M, Sanchez H, Moncollin V, Corneloup C, Richard-Bulteau H, Vignaud A, Baas D, Defour A, Freyssenet D, Tanti JF, Le-Marchand-Brustel Y, Ferrier B, Conjard-Duplany A, Romanino K, Bauché S, Hantaï D, Mueller M, Kozma SC, Thomas G, Rüegg MA, Ferry A, Pende M, Bigard X, Koulmann N, Schaeffer L, Gangloff YG. Risson V, et al. Among authors: mazelin l. J Cell Biol. 2009 Dec 14;187(6):859-74. doi: 10.1083/jcb.200903131. J Cell Biol. 2009. PMID: 20008564 Free PMC article.
mTOR inactivation in myocardium from infant mice rapidly leads to dilated cardiomyopathy due to translation defects and p53/JNK-mediated apoptosis.
Mazelin L, Panthu B, Nicot AS, Belotti E, Tintignac L, Teixeira G, Zhang Q, Risson V, Baas D, Delaune E, Derumeaux G, Taillandier D, Ohlmann T, Ovize M, Gangloff YG, Schaeffer L. Mazelin L, et al. J Mol Cell Cardiol. 2016 Aug;97:213-25. doi: 10.1016/j.yjmcc.2016.04.011. Epub 2016 Apr 28. J Mol Cell Cardiol. 2016. PMID: 27133769
Hypothalamic-pituitary-adrenal axis activation and glucocorticoid-responsive gene expression in skeletal muscle and liver of Apc mice.
Martin A, Castells J, Allibert V, Emerit A, Zolotoff C, Cardot-Ruffino V, Gallot YS, Vernus B, Chauvet V, Bartholin L, Schaeffer L, Durieux AC, Hourdé C, Favier FB, Mazelin L, Freyssenet D. Martin A, et al. Among authors: mazelin l. J Cachexia Sarcopenia Muscle. 2022 Jun;13(3):1686-1703. doi: 10.1002/jcsm.12939. Epub 2022 Mar 11. J Cachexia Sarcopenia Muscle. 2022. PMID: 35277933 Free PMC article.
Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function.
Romanino K, Mazelin L, Albert V, Conjard-Duplany A, Lin S, Bentzinger CF, Handschin C, Puigserver P, Zorzato F, Schaeffer L, Gangloff YG, Rüegg MA. Romanino K, et al. Among authors: mazelin l. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20808-13. doi: 10.1073/pnas.1111448109. Epub 2011 Dec 5. Proc Natl Acad Sci U S A. 2011. PMID: 22143799 Free PMC article.
DCC constrains tumour progression via its dependence receptor activity.
Castets M, Broutier L, Molin Y, Brevet M, Chazot G, Gadot N, Paquet A, Mazelin L, Jarrosson-Wuilleme L, Scoazec JY, Bernet A, Mehlen P. Castets M, et al. Among authors: mazelin l. Nature. 2011 Dec 11;482(7386):534-7. doi: 10.1038/nature10708. Nature. 2011. PMID: 22158121
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