Upchurch CM - Search Results

1

Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism.

Yeudall S, Upchurch CM, Seegren PV, Pavelec CM, Greulich J, Lemke MC, Harris TE, Desai BN, Hoehn KL, Leitinger N. Yeudall S, et al. Among authors: upchurch cm. Sci Adv. 2022 Nov 25;8(47):eabq1984. doi: 10.1126/sciadv.abq1984. Epub 2022 Nov 23. Sci Adv. 2022. PMID: 36417534 Free PMC article.

2

Macrophages sensing oxidized DAMPs reprogram their metabolism to support redox homeostasis and inflammation through a TLR2-Syk-ceramide dependent mechanism.

Serbulea V, Upchurch CM, Ahern KW, Bories G, Voigt P, DeWeese DE, Meher AK, Harris TE, Leitinger N. Serbulea V, et al. Among authors: upchurch cm. Mol Metab. 2018 Jan;7:23-34. doi: 10.1016/j.molmet.2017.11.002. Epub 2017 Nov 7. Mol Metab. 2018. PMID: 29153923 Free PMC article.

3

Macrophage phenotype and bioenergetics are controlled by oxidized phospholipids identified in lean and obese adipose tissue.

Serbulea V, Upchurch CM, Schappe MS, Voigt P, DeWeese DE, Desai BN, Meher AK, Leitinger N. Serbulea V, et al. Among authors: upchurch cm. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6254-E6263. doi: 10.1073/pnas.1800544115. Epub 2018 Jun 11. Proc Natl Acad Sci U S A. 2018. PMID: 29891687 Free PMC article.

4

Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2.

Kreutzberger AJB, Kiessling V, Doyle CA, Schenk N, Upchurch CM, Elmer-Dixon M, Ward AE, Preobraschenski J, Hussein SS, Tomaka W, Seelheim P, Kattan I, Harris M, Liang B, Kenworthy AK, Desai BN, Leitinger N, Anantharam A, Castle JD, Tamm LK. Kreutzberger AJB, et al. Among authors: upchurch cm. Elife. 2020 Nov 9;9:e62506. doi: 10.7554/eLife.62506. Elife. 2020. PMID: 33164744 Free PMC article.

5

Mitochondrial Ca²⁺ Signaling Is an Electrometabolic Switch to Fuel Phagosome Killing.

Seegren PV, Downs TK, Stremska ME, Harper LR, Cao R, Olson RJ, Upchurch CM, Doyle CA, Kennedy J, Stipes EL, Leitinger N, Periasamy A, Desai BN. Seegren PV, et al. Among authors: upchurch cm. Cell Rep. 2020 Nov 24;33(8):108411. doi: 10.1016/j.celrep.2020.108411. Cell Rep. 2020. PMID: 33238121 Free PMC article.

6

Adaptive thermogenesis in brown adipose tissue involves activation of pannexin-1 channels.

Senthivinayagam S, Serbulea V, Upchurch CM, Polanowska-Grabowska R, Mendu SK, Sahu S, Jayaguru P, Aylor KW, Chordia MD, Steinberg L, Oberholtzer N, Uchiyama S, Inada N, Lorenz UM, Harris TE, Keller SR, Meher AK, Kadl A, Desai BN, Kundu BK, Leitinger N. Senthivinayagam S, et al. Among authors: upchurch cm. Mol Metab. 2021 Feb;44:101130. doi: 10.1016/j.molmet.2020.101130. Epub 2020 Nov 25. Mol Metab. 2021. PMID: 33248294 Free PMC article.

7

Impact of a short-term low calorie diet alone or with interval exercise on quality of life and oxidized phospholipids in obese females.

Gilbertson NM, Eichner NZM, Gaitán JM, Pirtle JM, Kirby JL, Upchurch CM, Leitinger N, Malin SK. Gilbertson NM, et al. Among authors: upchurch cm. Physiol Behav. 2022 Mar 15;246:113706. doi: 10.1016/j.physbeh.2022.113706. Epub 2022 Jan 13. Physiol Behav. 2022. PMID: 35033556 Free PMC article. Clinical Trial.

8

Targeting oxidized phospholipids by AAV-based gene therapy in mice with established hepatic steatosis prevents progression to fibrosis.

Upchurch CM, Yeudall S, Pavelec CM, Merk D, Greulich J, Manjegowda M, Raghavan SS, Bochkis IM, Scott MM, Perez-Reyes E, Leitinger N. Upchurch CM, et al. Sci Adv. 2022 Jul 15;8(28):eabn0050. doi: 10.1126/sciadv.abn0050. Epub 2022 Jul 15. Sci Adv. 2022. PMID: 35857497 Free PMC article.

9

BAFF antagonism via the BAFF receptor 3 binding site attenuates BAFF 60-mer-induced classical NF-κB signaling and metabolic reprogramming of B cells.

D Lempicki M, Paul S, Serbulea V, Upchurch CM, Sahu S, Gray JA, Ailawadi G, Garcia BL, McNamara CA, Leitinger N, Meher AK. D Lempicki M, et al. Among authors: upchurch cm. Cell Immunol. 2022 Sep 9;381:104603. doi: 10.1016/j.cellimm.2022.104603. Online ahead of print. Cell Immunol. 2022. PMID: 36182705 Free PMC article.

10

Endocannabinoid biosynthetic enzymes regulate pain response via LKB1-AMPK signaling.

Chen M, Shin M, Ware TB, Donvito G, Muchhala KH, Mischel R, Mustafa MA, Serbulea V, Upchurch CM, Leitinger N, Akbarali HI, Lichtman AH, Hsu KL. Chen M, et al. Among authors: upchurch cm. Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2304900120. doi: 10.1073/pnas.2304900120. Epub 2023 Dec 18. Proc Natl Acad Sci U S A. 2023. PMID: 38109529

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