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The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6.
Tsujimoto K, Jo T, Nagira D, Konaka H, Park JH, Yoshimura SI, Ninomiya A, Sugihara F, Hirayama T, Itotagawa E, Matsuzaki Y, Takaichi Y, Aoki W, Saita S, Nakamura S, Ballabio A, Nada S, Okada M, Takamatsu H, Kumanogoh A. Tsujimoto K, et al. Among authors: ninomiya a. EMBO J. 2023 Jan 4;42(1):e111389. doi: 10.15252/embj.2022111389. Epub 2022 Nov 29. EMBO J. 2023. PMID: 36444797 Free PMC article.
SLPI is a critical mediator that controls PTH-induced bone formation.
Morimoto A, Kikuta J, Nishikawa K, Sudo T, Uenaka M, Furuya M, Hasegawa T, Hashimoto K, Tsukazaki H, Seno S, Nakamura A, Okuzaki D, Sugihara F, Ninomiya A, Yoshimura T, Takao-Kawabata R, Matsuda H, Ishii M. Morimoto A, et al. Among authors: ninomiya a. Nat Commun. 2021 Apr 9;12(1):2136. doi: 10.1038/s41467-021-22402-x. Nat Commun. 2021. PMID: 33837198 Free PMC article.
AAV-based gene therapy ameliorated CNS-specific GPI defect in mouse models.
Murakami Y, Umeshita S, Imanishi K, Yoshioka Y, Ninomiya A, Sunabori T, Likhite S, Koike M, Meyer KC, Kinoshita T. Murakami Y, et al. Among authors: ninomiya a. Mol Ther Methods Clin Dev. 2023 Dec 14;32(1):101176. doi: 10.1016/j.omtm.2023.101176. eCollection 2024 Mar 14. Mol Ther Methods Clin Dev. 2023. PMID: 38225934 Free PMC article.
Loss of the N-acetylgalactosamine side chain of the GPI-anchor impairs bone formation and brain functions and accelerates the prion disease pathology.
Hirata T, Kobayashi A, Furuse T, Yamada I, Tamura M, Tomita H, Tokoro Y, Ninomiya A, Fujihara Y, Ikawa M, Maeda Y, Murakami Y, Kizuka Y, Kinoshita T. Hirata T, et al. Among authors: ninomiya a. J Biol Chem. 2022 Mar;298(3):101720. doi: 10.1016/j.jbc.2022.101720. Epub 2022 Feb 11. J Biol Chem. 2022. PMID: 35151686 Free PMC article.
136 results