Zhang X - Search Results

1

Mutant NPM1 Hijacks Transcriptional Hubs to Maintain Pathogenic Gene Programs in Acute Myeloid Leukemia.

Wang XQD, Fan D, Han Q, Liu Y, Miao H, Wang X, Li Q, Chen D, Gore H, Himadewi P, Pfeifer GP, Cierpicki T, Grembecka J, Su J, Chong S, Wan L, Zhang X. Wang XQD, et al. Among authors: zhang x. Cancer Discov. 2023 Mar 1;13(3):724-745. doi: 10.1158/2159-8290.CD-22-0424. Cancer Discov. 2023. PMID: 36455589 Free PMC article.

2

Homeobox oncogene activation by pan-cancer DNA hypermethylation.

Su J, Huang YH, Cui X, Wang X, Zhang X, Lei Y, Xu J, Lin X, Chen K, Lv J, Goodell MA, Li W. Su J, et al. Among authors: zhang x. Genome Biol. 2018 Aug 10;19(1):108. doi: 10.1186/s13059-018-1492-3. Genome Biol. 2018. PMID: 30097071 Free PMC article.

3

Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis.

Zhang X, Wang X, Wang XQD, Su J, Putluri N, Zhou T, Qu Y, Jeong M, Guzman A, Rosas C, Huang Y, Sreekumar A, Li W, Goodell MA. Zhang X, et al. Blood. 2020 Mar 12;135(11):845-856. doi: 10.1182/blood.2019003330. Blood. 2020. PMID: 31932841 Free PMC article.

4

Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity.

Zhang X, Jeong M, Huang X, Wang XQ, Wang X, Zhou W, Shamim MS, Gore H, Himadewi P, Liu Y, Bochkov ID, Reyes J, Doty M, Huang YH, Jung H, Heikamp E, Aiden AP, Li W, Su J, Aiden EL, Goodell MA. Zhang X, et al. Mol Cell. 2020 May 7;78(3):506-521.e6. doi: 10.1016/j.molcel.2020.04.018. Mol Cell. 2020. PMID: 32386543 Free PMC article.

5

Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain.

Shukla S, Ying W, Gray F, Yao Y, Simes ML, Zhao Q, Miao H, Cho HJ, González-Alonso P, Winkler A, Lund G, Purohit T, Kim E, Zhang X, Ray JM, He S, Nikolaidis C, Ndoj J, Wang J, Jaremko Ł, Jaremko M, Ryan RJH, Guzman ML, Grembecka J, Cierpicki T. Shukla S, et al. Among authors: zhang x. Nat Chem Biol. 2021 Jul;17(7):784-793. doi: 10.1038/s41589-021-00815-5. Epub 2021 Jun 21. Nat Chem Biol. 2021. PMID: 34155404 Free PMC article.

6

3'HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression.

Himadewi P, Wang XQD, Feng F, Gore H, Liu Y, Yu L, Kurita R, Nakamura Y, Pfeifer GP, Liu J, Zhang X. Himadewi P, et al. Among authors: zhang x. Elife. 2021 Sep 29;10:e70557. doi: 10.7554/eLife.70557. Elife. 2021. PMID: 34585664 Free PMC article.

7

Connecting high-resolution 3D chromatin organization with epigenomics.

Feng F, Yao Y, Wang XQD, Zhang X, Liu J. Feng F, et al. Among authors: zhang x. Nat Commun. 2022 Apr 19;13(1):2054. doi: 10.1038/s41467-022-29695-6. Nat Commun. 2022. PMID: 35440119 Free PMC article.

8

DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells.

Zhang X, Su J, Jeong M, Ko M, Huang Y, Park HJ, Guzman A, Lei Y, Huang YH, Rao A, Li W, Goodell MA. Zhang X, et al. Nat Genet. 2016 Sep;48(9):1014-23. doi: 10.1038/ng.3610. Epub 2016 Jul 18. Nat Genet. 2016. PMID: 27428748 Free PMC article.

9

Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein.

Lei Y, Zhang X, Su J, Jeong M, Gundry MC, Huang YH, Zhou Y, Li W, Goodell MA. Lei Y, et al. Among authors: zhang x. Nat Commun. 2017 Jul 11;8:16026. doi: 10.1038/ncomms16026. Nat Commun. 2017. PMID: 28695892 Free PMC article.

10

DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A.

Huang YH, Su J, Lei Y, Brunetti L, Gundry MC, Zhang X, Jeong M, Li W, Goodell MA. Huang YH, et al. Among authors: zhang x. Genome Biol. 2017 Sep 18;18(1):176. doi: 10.1186/s13059-017-1306-z. Genome Biol. 2017. PMID: 28923089 Free PMC article.

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