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FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2.
Brevini T, Maes M, Webb GJ, John BV, Fuchs CD, Buescher G, Wang L, Griffiths C, Brown ML, Scott WE 3rd, Pereyra-Gerber P, Gelson WTH, Brown S, Dillon S, Muraro D, Sharp J, Neary M, Box H, Tatham L, Stewart J, Curley P, Pertinez H, Forrest S, Mlcochova P, Varankar SS, Darvish-Damavandi M, Mulcahy VL, Kuc RE, Williams TL, Heslop JA, Rossetti D, Tysoe OC, Galanakis V, Vila-Gonzalez M, Crozier TWM, Bargehr J, Sinha S, Upponi SS, Fear C, Swift L, Saeb-Parsy K, Davies SE, Wester A, Hagström H, Melum E, Clements D, Humphreys P, Herriott J, Kijak E, Cox H, Bramwell C, Valentijn A, Illingworth CJR; UK-PBC Consortium; Dahman B, Bastaich DR, Ferreira RD, Marjot T, Barnes E, Moon AM, Barritt AS 4th, Gupta RK, Baker S, Davenport AP, Corbett G, Gorgoulis VG, Buczacki SJA, Lee JH, Matheson NJ, Trauner M, Fisher AJ, Gibbs P, Butler AJ, Watson CJE, Mells GF, Dougan G, Owen A, Lohse AW, Vallier L, Sampaziotis F. Brevini T, et al. Among authors: sharp j. Nature. 2023 Mar;615(7950):134-142. doi: 10.1038/s41586-022-05594-0. Epub 2022 Dec 5. Nature. 2023. PMID: 36470304 Free PMC article.
Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2.
Gaynor KU, Vaysburd M, Harman MAJ, Albecka A, Jeffrey P, Beswick P, Papa G, Chen L, Mallery D, McGuinness B, Van Rietschoten K, Stanway S, Brear P, Lulla A, Ciazynska K, Chang VT, Sharp J, Neary M, Box H, Herriott J, Kijak E, Tatham L, Bentley EG, Sharma P, Kirby A, Han X, Stewart JP, Owen A, Briggs JAG, Hyvönen M, Skynner MJ, James LC. Gaynor KU, et al. Among authors: sharp j. Nat Commun. 2023 Jun 16;14(1):3583. doi: 10.1038/s41467-023-39158-1. Nat Commun. 2023. PMID: 37328472 Free PMC article.
Bulimia-induced dental erosion in a male patient.
Bidwell HL, Dent CD, Sharp JG. Bidwell HL, et al. Among authors: sharp jg. Quintessence Int. 1999 Feb;30(2):135-8. Quintessence Int. 1999. PMID: 10356565 No abstract available.
Evaluation of hospital-onset bacteraemia and fungaemia in the USA as a potential healthcare quality measure: a cross-sectional study.
Leekha S, Robinson GL, Jacob JT, Fridkin S, Shane A, Sick-Samuels A, Milstone AM, Nair R, Perencevich E, Puig-Asensio M, Kobayashi T, Mayer J, Lewis J, Bleasdale S, Wenzler E, Mena Lora AJ, Baghdadi J, Schrank GM, Wilber E, Aldredge AA, Sharp J, Dyer KE, Kendrick L, Ambalam V, Borgetti S, Carmack A, Gushiken A, Patel A, Reddy S, Brown CH, Dantes RB, Harris AD; CDC Prevention Epicenters Program. Leekha S, et al. Among authors: sharp j. BMJ Qual Saf. 2024 May 23:bmjqs-2023-016831. doi: 10.1136/bmjqs-2023-016831. Online ahead of print. BMJ Qual Saf. 2024. PMID: 38782579 Free article.
Five-year recurrence/survival after pancreatoduodenectomy for pancreatic adenocarcinoma: does pre-existing diabetes matter? Results from the Recurrence After Whipple's (RAW) study.
Rajagopalan A, Aroori S, Russell TB, Labib PL, Ausania F, Pando E, Roberts KJ, Kausar A, Mavroeidis VK, Marangoni G, Thomasset SC, Frampton AE, Lykoudis P, Maglione M, Alhaboob N, Bari H, Smith AM, Spalding D, Srinivasan P, Davidson BR, Bhogal RH, Dominguez I, Thakkar R, Gomez D, Silva MA, Lapolla P, Mingoli A, Porcu A, Shah NS, Hamady ZZR, Al-Sarrieh B, Serrablo A, Croagh D; RAW Study Collaborators. Rajagopalan A, et al. HPB (Oxford). 2024 Apr 26:S1365-182X(24)01276-0. doi: 10.1016/j.hpb.2024.04.010. Online ahead of print. HPB (Oxford). 2024. PMID: 38755085
Patterns, timing and predictors of recurrence following pancreaticoduodenectomy for distal cholangiocarcinoma: An international multicentre retrospective cohort study.
Labib PL, Russell TB, Denson JL, Puckett MA, Ausania F, Pando E, Roberts KJ, Kausar A, Mavroeidis VK, Bhogal RH, Marangoni G, Thomasset SC, Frampton AE, Spalding DR, Lykoudis P, Bellotti R, Alhaboob N, Srinivasan P, Bari H, Smith A, Dominguez-Rosado I, Croagh D, Thakkar RG, Gomez D, Silva MA, Lapolla P, Mingoli A, Davidson BR, Porcu A, Shah NS, Hamady ZZ, Al-Sarireh BA, Serrablo A; RAW study collaborators; Aroori S. Labib PL, et al. Eur J Surg Oncol. 2024 Jun;50(6):108353. doi: 10.1016/j.ejso.2024.108353. Epub 2024 Apr 22. Eur J Surg Oncol. 2024. PMID: 38701690
1,694 results