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Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage.
Ferreira-Gonzalez S, Man TY, Esser H, Aird R, Kilpatrick AM, Rodrigo-Torres D, Younger N, Campana L, Gadd VL, Dwyer B, Aleksieva N, Boulter L, Macmillan MT, Wang Y, Mylonas KJ, Ferenbach DA, Kendall TJ, Lu WY, Acosta JC, Kurian D, O'Neill S, Oniscu GC, Banales JM, Krimpenfort PJ, Forbes SJ. Ferreira-Gonzalez S, et al. Among authors: acosta jc. Sci Transl Med. 2022 Dec 7;14(674):eabj4375. doi: 10.1126/scitranslmed.abj4375. Epub 2022 Dec 7. Sci Transl Med. 2022. PMID: 36475903
Paracrine cellular senescence exacerbates biliary injury and impairs regeneration.
Ferreira-Gonzalez S, Lu WY, Raven A, Dwyer B, Man TY, O'Duibhir E, Lewis PJS, Campana L, Kendall TJ, Bird TG, Tarrats N, Acosta JC, Boulter L, Forbes SJ. Ferreira-Gonzalez S, et al. Among authors: acosta jc. Nat Commun. 2018 Mar 9;9(1):1020. doi: 10.1038/s41467-018-03299-5. Nat Commun. 2018. PMID: 29523787 Free PMC article.
Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence.
Fernández-Duran I, Quintanilla A, Tarrats N, Birch J, Hari P, Millar FR, Lagnado AB, Smer-Barreto V, Muir M, Brunton VG, Passos JF, Acosta JC. Fernández-Duran I, et al. Among authors: acosta jc. Cell Death Differ. 2022 Jun;29(6):1267-1282. doi: 10.1038/s41418-021-00917-6. Epub 2021 Dec 16. Cell Death Differ. 2022. PMID: 34916628 Free PMC article.
In Vivo Modeling of Patient Genetic Heterogeneity Identifies New Ways to Target Cholangiocarcinoma.
Younger NT, Wilson ML, Martinez Lyons A, Jarman EJ, Meynert AM, Grimes GR, Gournopanos K, Waddell SH, Tennant PA, Wilson DH, Guest RV, Wigmore SJ, Acosta JC, Kendall TJ, Taylor MS, Sproul D, Mill P, Boulter L. Younger NT, et al. Among authors: acosta jc. Cancer Res. 2022 Apr 15;82(8):1548-1559. doi: 10.1158/0008-5472.CAN-21-2556. Cancer Res. 2022. PMID: 35074757 Free PMC article.
Toll-like receptor 2 orchestrates a tumor suppressor response in non-small cell lung cancer.
Millar FR, Pennycuick A, Muir M, Quintanilla A, Hari P, Freyer E, Gautier P, Meynert A, Grimes G, Coll CS, Zdral S, Victorelli S, Teixeira VH, Connelly J, Passos JF, Ros MA, Wallace WAH, Frame MC, Sims AH, Boulter L, Janes SM, Wilkinson S, Acosta JC. Millar FR, et al. Among authors: acosta jc. Cell Rep. 2022 Nov 8;41(6):111596. doi: 10.1016/j.celrep.2022.111596. Cell Rep. 2022. PMID: 36351380 Free PMC article.
Discovery of senolytics using machine learning.
Smer-Barreto V, Quintanilla A, Elliott RJR, Dawson JC, Sun J, Campa VM, Lorente-Macías Á, Unciti-Broceta A, Carragher NO, Acosta JC, Oyarzún DA. Smer-Barreto V, et al. Among authors: acosta jc. Nat Commun. 2023 Jun 10;14(1):3445. doi: 10.1038/s41467-023-39120-1. Nat Commun. 2023. PMID: 37301862 Free PMC article.
Senescence: a new weapon for cancer therapy.
Acosta JC, Gil J. Acosta JC, et al. Trends Cell Biol. 2012 Apr;22(4):211-9. doi: 10.1016/j.tcb.2011.11.006. Epub 2012 Jan 13. Trends Cell Biol. 2012. PMID: 22245068 Review.
Measuring the Inflammasome in Oncogene-Induced Senescence.
Fernández-Duran I, Tarrats N, Hari P, Acosta JC. Fernández-Duran I, et al. Among authors: acosta jc. Methods Mol Biol. 2019;1896:57-70. doi: 10.1007/978-1-4939-8931-7_7. Methods Mol Biol. 2019. PMID: 30474840
84 results