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Page 1
Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage.
Ferreira-Gonzalez S, Man TY, Esser H, Aird R, Kilpatrick AM, Rodrigo-Torres D, Younger N, Campana L, Gadd VL, Dwyer B, Aleksieva N, Boulter L, Macmillan MT, Wang Y, Mylonas KJ, Ferenbach DA, Kendall TJ, Lu WY, Acosta JC, Kurian D, O'Neill S, Oniscu GC, Banales JM, Krimpenfort PJ, Forbes SJ. Ferreira-Gonzalez S, et al. Sci Transl Med. 2022 Dec 7;14(674):eabj4375. doi: 10.1126/scitranslmed.abj4375. Epub 2022 Dec 7. Sci Transl Med. 2022. PMID: 36475903
Combination of G-CSF and a TLR4 inhibitor reduce inflammation and promote regeneration in a mouse model of ACLF.
Engelmann C, Habtesion A, Hassan M, Kerbert AJ, Hammerich L, Novelli S, Fidaleo M, Philips A, Davies N, Ferreira-Gonzalez S, Forbes SJ, Berg T, Andreola F, Jalan R. Engelmann C, et al. Among authors: ferreira gonzalez s. J Hepatol. 2022 Nov;77(5):1325-1338. doi: 10.1016/j.jhep.2022.07.006. Epub 2022 Jul 16. J Hepatol. 2022. PMID: 35843375 Free article.
Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease.
Hallett JM, Ferreira-Gonzalez S, Man TY, Kilpatrick AM, Esser H, Thirlwell K, Macmillan MT, Rodrigo-Torres D, Dwyer BJ, Gadd VL, Ashmore-Harris C, Lu WY, Thomson JP, Jansen MA, O'Duibhir E, Starkey Lewis PJ, Campana L, Aird RE, Bate TSR, Fraser AR, Campbell JDM, Oniscu GC, Hay DC, Callanan A, Forbes SJ. Hallett JM, et al. Among authors: ferreira gonzalez s. Cell Stem Cell. 2022 Mar 3;29(3):355-371.e10. doi: 10.1016/j.stem.2022.02.006. Cell Stem Cell. 2022. PMID: 35245467 Free PMC article.
Deletion of kif3a in CK19 positive cells leads to primary cilia loss, biliary cell proliferation and cystic liver lesions in TAA-treated mice.
Chen J, Cheng NC, Boland JA, Liu K, Kench JG, Watkins DN, Ferreira-Gonzalez S, Forbes SJ, McCaughan GW. Chen J, et al. Among authors: ferreira gonzalez s. Biochim Biophys Acta Mol Basis Dis. 2022 Apr 1;1868(4):166335. doi: 10.1016/j.bbadis.2021.166335. Epub 2021 Dec 30. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 34973373 Free article.
Notch-IGF1 signaling during liver regeneration drives biliary epithelial cell expansion and inhibits hepatocyte differentiation.
Minnis-Lyons SE, Ferreira-González S, Aleksieva N, Man TY, Gadd VL, Williams MJ, Guest RV, Lu WY, Dwyer BJ, Jamieson T, Nixon C, Van Hul N, Lemaigre FP, McCafferty J, Leclercq IA, Sansom OJ, Boulter L, Forbes SJ. Minnis-Lyons SE, et al. Among authors: ferreira gonzalez s. Sci Signal. 2021 Jun 22;14(688):eaay9185. doi: 10.1126/scisignal.aay9185. Sci Signal. 2021. PMID: 34158399
Dimethyl fumarate reduces hepatocyte senescence following paracetamol exposure.
Meseguer-Ripolles J, Lucendo-Villarin B, Tucker C, Ferreira-Gonzalez S, Homer N, Wang Y, Starkey Lewis PJ, M Toledo E, Mellado-Gomez E, Simpson J, Flint O, Jaiswal H, Beer NL, Karlsen AE, Forbes SJ, Dear JW, Hughes J, Hay DC. Meseguer-Ripolles J, et al. Among authors: ferreira gonzalez s. iScience. 2021 May 19;24(6):102552. doi: 10.1016/j.isci.2021.102552. eCollection 2021 Jun 25. iScience. 2021. PMID: 34151225 Free PMC article.
Downregulation of TGR5 (GPBAR1) in biliary epithelial cells contributes to the pathogenesis of sclerosing cholangitis.
Reich M, Spomer L, Klindt C, Fuchs K, Stindt J, Deutschmann K, Höhne J, Liaskou E, Hov JR, Karlsen TH, Beuers U, Verheij J, Ferreira-Gonzalez S, Hirschfield G, Forbes SJ, Schramm C, Esposito I, Nierhoff D, Fickert P, Fuchs CD, Trauner M, García-Beccaria M, Gabernet G, Nahnsen S, Mallm JP, Vogel M, Schoonjans K, Lautwein T, Köhrer K, Häussinger D, Luedde T, Heikenwalder M, Keitel V. Reich M, et al. Among authors: ferreira gonzalez s. J Hepatol. 2021 Sep;75(3):634-646. doi: 10.1016/j.jhep.2021.03.029. Epub 2021 Apr 17. J Hepatol. 2021. PMID: 33872692 Free article.
Cellular Senescence in Liver Disease and Regeneration.
Ferreira-Gonzalez S, Rodrigo-Torres D, Gadd VL, Forbes SJ. Ferreira-Gonzalez S, et al. Semin Liver Dis. 2021 Jan;41(1):50-66. doi: 10.1055/s-0040-1722262. Epub 2021 Feb 9. Semin Liver Dis. 2021. PMID: 33764485 Free article. Review.
Fibroblast growth factor 7 releasing particles enhance islet engraftment and improve metabolic control following islet transplantation in mice with diabetes.
Alwahsh SM, Qutachi O, Starkey Lewis PJ, Bond A, Noble J, Burgoyne P, Morton N, Carter R, Mann J, Ferreira-Gonzalez S, Alvarez-Paino M, Forbes SJ, Shakesheff KM, Forbes S. Alwahsh SM, et al. Among authors: ferreira gonzalez s. Am J Transplant. 2021 Sep;21(9):2950-2963. doi: 10.1111/ajt.16488. Epub 2021 Feb 2. Am J Transplant. 2021. PMID: 33428803 Free PMC article.
17 results