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Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage.
Ferreira-Gonzalez S, Man TY, Esser H, Aird R, Kilpatrick AM, Rodrigo-Torres D, Younger N, Campana L, Gadd VL, Dwyer B, Aleksieva N, Boulter L, Macmillan MT, Wang Y, Mylonas KJ, Ferenbach DA, Kendall TJ, Lu WY, Acosta JC, Kurian D, O'Neill S, Oniscu GC, Banales JM, Krimpenfort PJ, Forbes SJ. Ferreira-Gonzalez S, et al. Among authors: gadd vl. Sci Transl Med. 2022 Dec 7;14(674):eabj4375. doi: 10.1126/scitranslmed.abj4375. Epub 2022 Dec 7. Sci Transl Med. 2022. PMID: 36475903
Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease.
Hallett JM, Ferreira-Gonzalez S, Man TY, Kilpatrick AM, Esser H, Thirlwell K, Macmillan MT, Rodrigo-Torres D, Dwyer BJ, Gadd VL, Ashmore-Harris C, Lu WY, Thomson JP, Jansen MA, O'Duibhir E, Starkey Lewis PJ, Campana L, Aird RE, Bate TSR, Fraser AR, Campbell JDM, Oniscu GC, Hay DC, Callanan A, Forbes SJ. Hallett JM, et al. Among authors: gadd vl. Cell Stem Cell. 2022 Mar 3;29(3):355-371.e10. doi: 10.1016/j.stem.2022.02.006. Cell Stem Cell. 2022. PMID: 35245467 Free PMC article.
Notch-IGF1 signaling during liver regeneration drives biliary epithelial cell expansion and inhibits hepatocyte differentiation.
Minnis-Lyons SE, Ferreira-González S, Aleksieva N, Man TY, Gadd VL, Williams MJ, Guest RV, Lu WY, Dwyer BJ, Jamieson T, Nixon C, Van Hul N, Lemaigre FP, McCafferty J, Leclercq IA, Sansom OJ, Boulter L, Forbes SJ. Minnis-Lyons SE, et al. Among authors: gadd vl. Sci Signal. 2021 Jun 22;14(688):eaay9185. doi: 10.1126/scisignal.aay9185. Sci Signal. 2021. PMID: 34158399
Cellular Senescence in Liver Disease and Regeneration.
Ferreira-Gonzalez S, Rodrigo-Torres D, Gadd VL, Forbes SJ. Ferreira-Gonzalez S, et al. Among authors: gadd vl. Semin Liver Dis. 2021 Jan;41(1):50-66. doi: 10.1055/s-0040-1722262. Epub 2021 Feb 9. Semin Liver Dis. 2021. PMID: 33764485 Free article. Review.
17 results