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Senolytic treatment preserves biliary regenerative capacity lost through cellular senescence during cold storage.
Ferreira-Gonzalez S, Man TY, Esser H, Aird R, Kilpatrick AM, Rodrigo-Torres D, Younger N, Campana L, Gadd VL, Dwyer B, Aleksieva N, Boulter L, Macmillan MT, Wang Y, Mylonas KJ, Ferenbach DA, Kendall TJ, Lu WY, Acosta JC, Kurian D, O'Neill S, Oniscu GC, Banales JM, Krimpenfort PJ, Forbes SJ. Ferreira-Gonzalez S, et al. Among authors: kendall tj. Sci Transl Med. 2022 Dec 7;14(674):eabj4375. doi: 10.1126/scitranslmed.abj4375. Epub 2022 Dec 7. Sci Transl Med. 2022. PMID: 36475903
Hepatic progenitor cells of biliary origin with liver repopulation capacity.
Lu WY, Bird TG, Boulter L, Tsuchiya A, Cole AM, Hay T, Guest RV, Wojtacha D, Man TY, Mackinnon A, Ridgway RA, Kendall T, Williams MJ, Jamieson T, Raven A, Hay DC, Iredale JP, Clarke AR, Sansom OJ, Forbes SJ. Lu WY, et al. Nat Cell Biol. 2015 Aug;17(8):971-983. doi: 10.1038/ncb3203. Epub 2015 Jul 20. Nat Cell Biol. 2015. PMID: 26192438 Free PMC article.
Notch3 drives development and progression of cholangiocarcinoma.
Guest RV, Boulter L, Dwyer BJ, Kendall TJ, Man TY, Minnis-Lyons SE, Lu WY, Robson AJ, Gonzalez SF, Raven A, Wojtacha D, Morton JP, Komuta M, Roskams T, Wigmore SJ, Sansom OJ, Forbes SJ. Guest RV, et al. Among authors: kendall tj. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12250-12255. doi: 10.1073/pnas.1600067113. Epub 2016 Oct 10. Proc Natl Acad Sci U S A. 2016. PMID: 27791012 Free PMC article.
11Beta-hydroxysteroid dehydrogenase-1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis.
Zou X, Ramachandran P, Kendall TJ, Pellicoro A, Dora E, Aucott RL, Manwani K, Man TY, Chapman KE, Henderson NC, Forbes SJ, Webster SP, Iredale JP, Walker BR, Michailidou Z. Zou X, et al. Among authors: kendall tj. Hepatology. 2018 Jun;67(6):2167-2181. doi: 10.1002/hep.29734. Epub 2018 Feb 22. Hepatology. 2018. PMID: 29251794 Free PMC article.
The STAT3-IL-10-IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury.
Campana L, Starkey Lewis PJ, Pellicoro A, Aucott RL, Man J, O'Duibhir E, Mok SE, Ferreira-Gonzalez S, Livingstone E, Greenhalgh SN, Hull KL, Kendall TJ, Vernimmen D, Henderson NC, Boulter L, Gregory CD, Feng Y, Anderton SM, Forbes SJ, Iredale JP. Campana L, et al. Among authors: kendall tj. J Immunol. 2018 Feb 1;200(3):1169-1187. doi: 10.4049/jimmunol.1701247. Epub 2017 Dec 20. J Immunol. 2018. PMID: 29263216 Free PMC article.
Paracrine cellular senescence exacerbates biliary injury and impairs regeneration.
Ferreira-Gonzalez S, Lu WY, Raven A, Dwyer B, Man TY, O'Duibhir E, Lewis PJS, Campana L, Kendall TJ, Bird TG, Tarrats N, Acosta JC, Boulter L, Forbes SJ. Ferreira-Gonzalez S, et al. Among authors: kendall tj. Nat Commun. 2018 Mar 9;9(1):1020. doi: 10.1038/s41467-018-03299-5. Nat Commun. 2018. PMID: 29523787 Free PMC article.
Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors.
Wilson DH, Jarman EJ, Mellin RP, Wilson ML, Waddell SH, Tsokkou P, Younger NT, Raven A, Bhalla SR, Noll ATR, Olde Damink SW, Schaap FG, Chen P, Bates DO, Banales JM, Dean CH, Henderson DJ, Sansom OJ, Kendall TJ, Boulter L. Wilson DH, et al. Among authors: kendall tj. Nat Commun. 2020 Jan 23;11(1):445. doi: 10.1038/s41467-020-14283-3. Nat Commun. 2020. PMID: 31974352 Free PMC article.
Alternatively activated macrophages promote resolution of necrosis following acute liver injury.
Starkey Lewis P, Campana L, Aleksieva N, Cartwright JA, Mackinnon A, O'Duibhir E, Kendall T, Vermeren M, Thomson A, Gadd V, Dwyer B, Aird R, Man TY, Rossi AG, Forrester L, Park BK, Forbes SJ. Starkey Lewis P, et al. J Hepatol. 2020 Aug;73(2):349-360. doi: 10.1016/j.jhep.2020.02.031. Epub 2020 Mar 11. J Hepatol. 2020. PMID: 32169610 Free PMC article.
80 results