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Sphingosine Kinase 1 Deficiency in Smooth Muscle Cells Protects against Hypoxia-Mediated Pulmonary Hypertension via YAP1 Signaling.
Chen J, Lockett A, Zhao S, Huang LS, Wang Y, Wu W, Tang M, Haider S, Velez Rendon D, Khan R, Liu B, Felesena N, Sysol JR, Valdez-Jasso D, Tang H, Bai Y, Natarajan V, Machado RF. Chen J, et al. Among authors: natarajan v. Int J Mol Sci. 2022 Nov 22;23(23):14516. doi: 10.3390/ijms232314516. Int J Mol Sci. 2022. PMID: 36498853 Free PMC article.
The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.
Chen J, Tang H, Sysol JR, Moreno-Vinasco L, Shioura KM, Chen T, Gorshkova I, Wang L, Huang LS, Usatyuk PV, Sammani S, Zhou G, Raj JU, Garcia JG, Berdyshev E, Yuan JX, Natarajan V, Machado RF. Chen J, et al. Among authors: natarajan v. Am J Respir Crit Care Med. 2014 Nov 1;190(9):1032-43. doi: 10.1164/rccm.201401-0121OC. Am J Respir Crit Care Med. 2014. PMID: 25180446 Free PMC article.
Sphingosine Kinase 1/S1P Signaling Contributes to Pulmonary Fibrosis by Activating Hippo/YAP Pathway and Mitochondrial Reactive Oxygen Species in Lung Fibroblasts.
Huang LS, Sudhadevi T, Fu P, Punathil-Kannan PK, Ebenezer DL, Ramchandran R, Putherickal V, Cheresh P, Zhou G, Ha AW, Harijith A, Kamp DW, Natarajan V. Huang LS, et al. Among authors: natarajan v. Int J Mol Sci. 2020 Mar 17;21(6):2064. doi: 10.3390/ijms21062064. Int J Mol Sci. 2020. PMID: 32192225 Free PMC article.
Sphingolipids in pulmonary fibrosis.
Huang LS, Natarajan V. Huang LS, et al. Among authors: natarajan v. Adv Biol Regul. 2015 Jan;57:55-63. doi: 10.1016/j.jbior.2014.09.008. Epub 2014 Oct 13. Adv Biol Regul. 2015. PMID: 25446881 Free PMC article. Review.
The Sphingosine Kinase 1 Inhibitor, PF543, Mitigates Pulmonary Fibrosis by Reducing Lung Epithelial Cell mtDNA Damage and Recruitment of Fibrogenic Monocytes.
Cheresh P, Kim SJ, Huang LS, Watanabe S, Joshi N, Williams KJN, Chi M, Lu Z, Harijith A, Yeldandi A, Lam AP, Gottardi C, Misharin AV, Budinger GRS, Natarajan V, Kamp DW. Cheresh P, et al. Among authors: natarajan v. Int J Mol Sci. 2020 Aug 5;21(16):5595. doi: 10.3390/ijms21165595. Int J Mol Sci. 2020. PMID: 32764262 Free PMC article.
Cortactin loss protects against hemin-induced acute lung injury in sickle cell disease.
Jones NM, Sysol JR, Singla S, Smith P, Sandusky GE, Wang H, Natarajan V, Dudek SM, Machado RF. Jones NM, et al. Among authors: natarajan v. Am J Physiol Lung Cell Mol Physiol. 2022 Jun 1;322(6):L890-L897. doi: 10.1152/ajplung.00274.2021. Epub 2022 May 3. Am J Physiol Lung Cell Mol Physiol. 2022. PMID: 35503995 Free PMC article.
Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis.
Huang LS, Berdyshev E, Mathew B, Fu P, Gorshkova IA, He D, Ma W, Noth I, Ma SF, Pendyala S, Reddy SP, Zhou T, Zhang W, Garzon SA, Garcia JG, Natarajan V. Huang LS, et al. Among authors: natarajan v. FASEB J. 2013 Apr;27(4):1749-60. doi: 10.1096/fj.12-219634. Epub 2013 Jan 11. FASEB J. 2013. PMID: 23315259 Free PMC article.
643 results