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Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis.
O'Sullivan ED, Mylonas KJ, Bell R, Carvalho C, Baird DP, Cairns C, Gallagher KM, Campbell R, Docherty M, Laird A, Henderson NC, Chandra T, Kirschner K, Conway B, Dihazi GH, Zeisberg M, Hughes J, Denby L, Dihazi H, Ferenbach DA. O'Sullivan ED, et al. Among authors: kirschner k. JCI Insight. 2022 Nov 22;7(22):e154124. doi: 10.1172/jci.insight.154124. JCI Insight. 2022. PMID: 36509292 Free PMC article.
Global reorganization of the nuclear landscape in senescent cells.
Chandra T, Ewels PA, Schoenfelder S, Furlan-Magaril M, Wingett SW, Kirschner K, Thuret JY, Andrews S, Fraser P, Reik W. Chandra T, et al. Among authors: kirschner k. Cell Rep. 2015 Feb 3;10(4):471-83. doi: 10.1016/j.celrep.2014.12.055. Epub 2015 Jan 29. Cell Rep. 2015. PMID: 25640177 Free PMC article.
Chromosome organisation during ageing and senescence.
Chandra T, Kirschner K. Chandra T, et al. Among authors: kirschner k. Curr Opin Cell Biol. 2016 Jun;40:161-167. doi: 10.1016/j.ceb.2016.03.020. Epub 2016 Apr 19. Curr Opin Cell Biol. 2016. PMID: 27101466 Free article. Review.
SC3: consensus clustering of single-cell RNA-seq data.
Kiselev VY, Kirschner K, Schaub MT, Andrews T, Yiu A, Chandra T, Natarajan KN, Reik W, Barahona M, Green AR, Hemberg M. Kiselev VY, et al. Among authors: kirschner k. Nat Methods. 2017 May;14(5):483-486. doi: 10.1038/nmeth.4236. Epub 2017 Mar 27. Nat Methods. 2017. PMID: 28346451 Free PMC article.
Experimental design for single-cell RNA sequencing.
Baran-Gale J, Chandra T, Kirschner K. Baran-Gale J, et al. Among authors: kirschner k. Brief Funct Genomics. 2018 Jul 1;17(4):233-239. doi: 10.1093/bfgp/elx035. Brief Funct Genomics. 2018. PMID: 29126257 Free PMC article. Review.
Notch Signaling Mediates Secondary Senescence.
Teo YV, Rattanavirotkul N, Olova N, Salzano A, Quintanilla A, Tarrats N, Kiourtis C, Müller M, Green AR, Adams PD, Acosta JC, Bird TG, Kirschner K, Neretti N, Chandra T. Teo YV, et al. Among authors: kirschner k. Cell Rep. 2019 Apr 23;27(4):997-1007.e5. doi: 10.1016/j.celrep.2019.03.104. Cell Rep. 2019. PMID: 31018144 Free PMC article.
Age-related clonal haemopoiesis is associated with increased epigenetic age.
Robertson NA, Hillary RF, McCartney DL, Terradas-Terradas M, Higham J, Sproul D, Deary IJ, Kirschner K, Marioni RE, Chandra T. Robertson NA, et al. Among authors: kirschner k. Curr Biol. 2019 Aug 19;29(16):R786-R787. doi: 10.1016/j.cub.2019.07.011. Curr Biol. 2019. PMID: 31430471 Free article.
Functional heterogeneity in senescence.
Kirschner K, Rattanavirotkul N, Quince MF, Chandra T. Kirschner K, et al. Biochem Soc Trans. 2020 Jun 30;48(3):765-773. doi: 10.1042/BST20190109. Biochem Soc Trans. 2020. PMID: 32369550 Free PMC article. Review.
319 results