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Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis.
O'Sullivan ED, Mylonas KJ, Bell R, Carvalho C, Baird DP, Cairns C, Gallagher KM, Campbell R, Docherty M, Laird A, Henderson NC, Chandra T, Kirschner K, Conway B, Dihazi GH, Zeisberg M, Hughes J, Denby L, Dihazi H, Ferenbach DA. O'Sullivan ED, et al. JCI Insight. 2022 Nov 22;7(22):e154124. doi: 10.1172/jci.insight.154124. JCI Insight. 2022. PMID: 36509292 Free PMC article.
Renal Aging: Causes and Consequences.
O'Sullivan ED, Hughes J, Ferenbach DA. O'Sullivan ED, et al. J Am Soc Nephrol. 2017 Feb;28(2):407-420. doi: 10.1681/ASN.2015121308. Epub 2016 Nov 15. J Am Soc Nephrol. 2017. PMID: 28143966 Free PMC article. Review.
Therapeutic Approaches to Aging.
O'Sullivan ED, Mylonas KJ, Ferenbach DA. O'Sullivan ED, et al. JAMA. 2019 Mar 5;321(9):901. doi: 10.1001/jama.2018.20550. JAMA. 2019. PMID: 30835302 No abstract available.
Cellular Senescence in the Kidney.
Docherty MH, O'Sullivan ED, Bonventre JV, Ferenbach DA. Docherty MH, et al. J Am Soc Nephrol. 2019 May;30(5):726-736. doi: 10.1681/ASN.2018121251. Epub 2019 Apr 18. J Am Soc Nephrol. 2019. PMID: 31000567 Free PMC article. Review.
Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease.
Conway BR, O'Sullivan ED, Cairns C, O'Sullivan J, Simpson DJ, Salzano A, Connor K, Ding P, Humphries D, Stewart K, Teenan O, Pius R, Henderson NC, Bénézech C, Ramachandran P, Ferenbach D, Hughes J, Chandra T, Denby L. Conway BR, et al. Among authors: o sullivan ed. J Am Soc Nephrol. 2020 Dec;31(12):2833-2854. doi: 10.1681/ASN.2020060806. Epub 2020 Sep 25. J Am Soc Nephrol. 2020. PMID: 32978267 Free PMC article.
Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis.
O'Sullivan ED, Mylonas KJ, Xin C, Baird DP, Carvalho C, Docherty MH, Campbell R, Matchett KP, Waddell SH, Walker AD, Gallagher KM, Jia S, Leung S, Laird A, Wilflingseder J, Willi M, Reck M, Finnie S, Pisco A, Gordon-Keylock S, Medvinsky A, Boulter L, Henderson NC, Kirschner K, Chandra T, Conway BR, Hughes J, Denby L, Bonventre JV, Ferenbach DA. O'Sullivan ED, et al. Sci Transl Med. 2023 May 31;15(698):eabn0736. doi: 10.1126/scitranslmed.abn0736. Epub 2023 May 31. Sci Transl Med. 2023. PMID: 37256934 Free article.
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