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Discovery and Development of a Selective Inhibitor of the ER Resident Chaperone Grp78.
Ambrose AJ, Sivinski J, Zerio CJ, Zhu X, Godek J, Kumirov VK, Coma Brujas T, Torra Garcia J, Annadurai A, Schmidlin CJ, Werner A, Shi T, Zavareh RB, Lairson L, Zhang DD, Chapman E. Ambrose AJ, et al. Among authors: lairson l. J Med Chem. 2023 Jan 12;66(1):677-694. doi: 10.1021/acs.jmedchem.2c01631. Epub 2022 Dec 14. J Med Chem. 2023. PMID: 36516003
Discovery of Small Molecules for the Reversal of T Cell Exhaustion.
Marro BS, Zak J, Zavareh RB, Teijaro JR, Lairson LL, Oldstone MBA. Marro BS, et al. Among authors: lairson ll. Cell Rep. 2019 Dec 3;29(10):3293-3302.e3. doi: 10.1016/j.celrep.2019.10.119. Cell Rep. 2019. PMID: 31801090 Free PMC article.
Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay.
Shirey RJ, Hart JR, Sridharan B, Novick SJ, Turner LD, Zhou B, Nielsen AL, Eubanks LM, Ueno L, Hixon MS, Lairson LL, Spicer TP, Scampavia LD, Griffin PR, Vogt PK, Janda KD. Shirey RJ, et al. Among authors: lairson ll. Bioorg Med Chem. 2021 Jul 15;42:116246. doi: 10.1016/j.bmc.2021.116246. Epub 2021 Jun 6. Bioorg Med Chem. 2021. PMID: 34130216 Free PMC article.
Human Hsp70 Substrate-Binding Domains Recognize Distinct Client Proteins.
Ambrose AJ, Zerio CJ, Sivinski J, Zhu X, Godek J, Sanchez JL, Khanna M, Khanna R, Lairson L, Zhang DD, Chapman E. Ambrose AJ, et al. Among authors: lairson l. Biochemistry. 2024 Feb 6;63(3):251-263. doi: 10.1021/acs.biochem.3c00531. Epub 2024 Jan 20. Biochemistry. 2024. PMID: 38243804
67 results