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Discovery and Development of a Selective Inhibitor of the ER Resident Chaperone Grp78.
Ambrose AJ, Sivinski J, Zerio CJ, Zhu X, Godek J, Kumirov VK, Coma Brujas T, Torra Garcia J, Annadurai A, Schmidlin CJ, Werner A, Shi T, Zavareh RB, Lairson L, Zhang DD, Chapman E. Ambrose AJ, et al. Among authors: sivinski j. J Med Chem. 2023 Jan 12;66(1):677-694. doi: 10.1021/acs.jmedchem.2c01631. Epub 2022 Dec 14. J Med Chem. 2023. PMID: 36516003
Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections.
Washburn A, Abdeen S, Ovechkina Y, Ray AM, Stevens M, Chitre S, Sivinski J, Park Y, Johnson J, Hoang QQ, Chapman E, Parish T, Johnson SM. Washburn A, et al. Among authors: sivinski j. Bioorg Med Chem Lett. 2019 Jul 1;29(13):1665-1672. doi: 10.1016/j.bmcl.2019.04.034. Epub 2019 Apr 24. Bioorg Med Chem Lett. 2019. PMID: 31047750 Free PMC article.
Analogs of nitrofuran antibiotics are potent GroEL/ES inhibitor pro-drugs.
Stevens M, Howe C, Ray AM, Washburn A, Chitre S, Sivinski J, Park Y, Hoang QQ, Chapman E, Johnson SM. Stevens M, et al. Among authors: sivinski j. Bioorg Med Chem. 2020 Nov 15;28(22):115710. doi: 10.1016/j.bmc.2020.115710. Epub 2020 Aug 30. Bioorg Med Chem. 2020. PMID: 33007545 Free PMC article.
Functional Differences between E. coli and ESKAPE Pathogen GroES/GroEL.
Sivinski J, Ambrose AJ, Panfilenko I, Zerio CJ, Machulis JM, Mollasalehi N, Kaneko LK, Stevens M, Ray AM, Park Y, Wu C, Hoang QQ, Johnson SM, Chapman E. Sivinski J, et al. mBio. 2021 Jan 12;12(1):e02167-20. doi: 10.1128/mBio.02167-20. mBio. 2021. PMID: 33436430 Free PMC article.
Targeting NRF2 to treat cancer.
Sivinski J, Zhang DD, Chapman E. Sivinski J, et al. Semin Cancer Biol. 2021 Nov;76:61-73. doi: 10.1016/j.semcancer.2021.06.003. Epub 2021 Jun 5. Semin Cancer Biol. 2021. PMID: 34102289 Free PMC article. Review.
A two-step resin based approach to reveal survivin-selective fluorescent probes.
Ambrose AJ, Pham NT, Sivinski J, Guimarães L, Mollasalehi N, Jimenez P, Abad MA, Jeyaprakash AA, Shave S, Costa-Lotufo LV, La Clair JJ, Auer M, Chapman E. Ambrose AJ, et al. Among authors: sivinski j. RSC Chem Biol. 2020 Nov 27;2(1):181-186. doi: 10.1039/d0cb00122h. eCollection 2021 Feb 1. RSC Chem Biol. 2020. PMID: 34458780 Free PMC article.
45 results