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Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children.
Ramaswamy A, Brodsky NN, Sumida TS, Comi M, Asashima H, Hoehn KB, Li N, Liu Y, Shah A, Ravindra NG, Bishai J, Khan A, Lau W, Sellers B, Bansal N, Guerrerio P, Unterman A, Habet V, Rice AJ, Catanzaro J, Chandnani H, Lopez M, Kaminski N, Dela Cruz CS, Tsang JS, Wang Z, Yan X, Kleinstein SH, van Dijk D, Pierce RW, Hafler DA, Lucas CL. Ramaswamy A, et al. Among authors: lucas cl. Immunity. 2021 May 11;54(5):1083-1095.e7. doi: 10.1016/j.immuni.2021.04.003. Epub 2021 Apr 13. Immunity. 2021. PMID: 33891889 Free PMC article.
PD-1highCXCR5-CD4+ peripheral helper T cells promote CXCR3+ plasmablasts in human acute viral infection.
Asashima H, Mohanty S, Comi M, Ruff WE, Hoehn KB, Wong P, Klein J, Lucas C, Cohen I, Coffey S, Lele N, Greta L, Raddassi K, Chaudhary O, Unterman A, Emu B, Kleinstein SH, Montgomery RR, Iwasaki A, Dela Cruz CS, Kaminski N, Shaw AC, Hafler DA, Sumida TS. Asashima H, et al. Cell Rep. 2023 Jan 31;42(1):111895. doi: 10.1016/j.celrep.2022.111895. Epub 2023 Jan 2. Cell Rep. 2023. PMID: 36596303 Free PMC article.
Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine-associated myocarditis.
Barmada A, Klein J, Ramaswamy A, Brodsky NN, Jaycox JR, Sheikha H, Jones KM, Habet V, Campbell M, Sumida TS, Kontorovich A, Bogunovic D, Oliveira CR, Steele J, Hall EK, Pena-Hernandez M, Monteiro V, Lucas C, Ring AM, Omer SB, Iwasaki A, Yildirim I, Lucas CL. Barmada A, et al. Among authors: lucas cl. Sci Immunol. 2023 May 12;8(83):eadh3455. doi: 10.1126/sciimmunol.adh3455. Epub 2023 May 5. Sci Immunol. 2023. PMID: 37146127 Free PMC article.
Post-infectious inflammatory disease in MIS-C features elevated cytotoxicity signatures and autoreactivity that correlates with severity.
Ramaswamy A, Brodsky NN, Sumida TS, Comi M, Asashima H, Hoehn KB, Li N, Liu Y, Shah A, Ravindra NG, Bishai J, Khan A, Lau W, Sellers B, Bansal N, Guerrerio P, Unterman A, Habet V, Rice AJ, Catanzaro J, Chandnani H, Lopez M, Kaminski N, Dela Cruz CS, Tsang JS, Wang Z, Yan X, Kleinstein SH, van Dijk D, Pierce RW, Hafler DA, Lucas CL. Ramaswamy A, et al. Among authors: lucas cl. medRxiv [Preprint]. 2021 Apr 3:2020.12.01.20241364. doi: 10.1101/2020.12.01.20241364. medRxiv. 2021. PMID: 33300011 Free PMC article. Updated. Preprint.
Maximizing insights from monogenic immune disorders.
Barmada A, Ramaswamy A, Lucas CL. Barmada A, et al. Among authors: lucas cl. Curr Opin Immunol. 2021 Dec;73:50-57. doi: 10.1016/j.coi.2021.09.008. Epub 2021 Oct 22. Curr Opin Immunol. 2021. PMID: 34695727 Free PMC article. Review.
A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice.
Mao T, Israelow B, Lucas C, Vogels CBF, Gomez-Calvo ML, Fedorova O, Breban MI, Menasche BL, Dong H, Linehan M; Yale SARS-CoV-2 Genome Surveillance Initiative; Wilen CB, Landry ML, Grubaugh ND, Pyle AM, Iwasaki A. Mao T, et al. J Exp Med. 2022 Jan 3;219(1):e20211818. doi: 10.1084/jem.20211818. Epub 2021 Nov 10. J Exp Med. 2022. PMID: 34757384 Free PMC article.
Age-dependent impairment in antibody responses elicited by a homologous CoronaVac booster dose.
Filardi BA, Monteiro VS, Schwartzmann PV, do Prado Martins V, Zucca LER, Baiocchi GC, Malik AA, Silva J, Hahn AM, Chen NFG, Pham K, Pérez-Then E, Miric M, Brache V, Cochon L, Larocca RA, Mendez RDR, Bardini Silveira D, Pinto AR, Croda J, Yildirim I, Omer SB, Ko AI, Vermund SH, Grubaugh ND, Iwasaki A, Lucas C; Yale SARS-CoV-2 Genomic Surveillance Initiative; Vogels CBF, Breban M, Koch TR, Chaguza C, Tikhonova I, Castaldi C, Mane S, De Kumar B, Ferguson D, Kerantzas N, Peaper D, Landry ML, Schulz W. Filardi BA, et al. Sci Transl Med. 2023 Feb 15;15(683):eade6023. doi: 10.1126/scitranslmed.ade6023. Epub 2023 Feb 15. Sci Transl Med. 2023. PMID: 36791210 Free article.
133 results