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Improved genome editing by an engineered CRISPR-Cas12a.
Ma E, Chen K, Shi H, Stahl EC, Adler B, Trinidad M, Liu J, Zhou K, Ye J, Doudna JA. Ma E, et al. Among authors: chen k. Nucleic Acids Res. 2022 Dec 9;50(22):12689-12701. doi: 10.1093/nar/gkac1192. Nucleic Acids Res. 2022. PMID: 36537251 Free PMC article.
Eukaryotic RNA-guided endonucleases evolved from a unique clade of bacterial enzymes.
Yoon PH, Skopintsev P, Shi H, Chen L, Adler BA, Al-Shimary M, Craig RJ, Loi KJ, DeTurk EC, Li Z, Amerasekera J, Trinidad M, Nisonoff H, Chen K, Lahiri A, Boger R, Jacobsen S, Banfield JF, Doudna JA. Yoon PH, et al. Among authors: chen k, chen l. Nucleic Acids Res. 2023 Dec 11;51(22):12414-12427. doi: 10.1093/nar/gkad1053. Nucleic Acids Res. 2023. PMID: 37971304 Free PMC article.
Rapid DNA unwinding accelerates genome editing by engineered CRISPR-Cas9.
Eggers AR, Chen K, Soczek KM, Tuck OT, Doherty EE, Thornton BW, Xu B, Trinidad MI, Doudna JA. Eggers AR, et al. Among authors: chen k. bioRxiv [Preprint]. 2023 Dec 15:2023.12.14.571777. doi: 10.1101/2023.12.14.571777. bioRxiv. 2023. PMID: 38168238 Free PMC article. Preprint.
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