Spigelman AF - Search Results

1

A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk.

Rottner AK, Ye Y, Navarro-Guerrero E, Rajesh V, Pollner A, Bevacqua RJ, Yang J, Spigelman AF, Baronio R, Bautista A, Thomsen SK, Lyon J, Nawaz S, Smith N, Wesolowska-Andersen A, Fox JEM, Sun H, Kim SK, Ebner D, MacDonald PE, Gloyn AL. Rottner AK, et al. Among authors: spigelman af. Nat Genet. 2023 Jan;55(1):54-65. doi: 10.1038/s41588-022-01261-2. Epub 2022 Dec 21. Nat Genet. 2023. PMID: 36543916 Free PMC article.

2

Voltage-dependent K(+) channels are positive regulators of alpha cell action potential generation and glucagon secretion in mice and humans.

Spigelman AF, Dai X, MacDonald PE. Spigelman AF, et al. Diabetologia. 2010 Sep;53(9):1917-26. doi: 10.1007/s00125-010-1759-z. Epub 2010 May 6. Diabetologia. 2010. PMID: 20446079

3

The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function.

Dai XQ, Manning Fox JE, Chikvashvili D, Casimir M, Plummer G, Hajmrle C, Spigelman AF, Kin T, Singer-Lahat D, Kang Y, Shapiro AM, Gaisano HY, Lotan I, Macdonald PE. Dai XQ, et al. Among authors: spigelman af. Diabetologia. 2012 Jun;55(6):1709-20. doi: 10.1007/s00125-012-2512-6. Epub 2012 Mar 13. Diabetologia. 2012. PMID: 22411134

4

Functional plasticity of the human infant β-cell exocytotic phenotype.

Fox JE, Seeberger K, Dai XQ, Lyon J, Spigelman AF, Kolic J, Hajmrle C, Joseph JW, Kin T, Shapiro AM, Korbutt G, MacDonald PE. Fox JE, et al. Among authors: spigelman af. Endocrinology. 2013 Apr;154(4):1392-9. doi: 10.1210/en.2012-1934. Epub 2013 Feb 28. Endocrinology. 2013. PMID: 23449893

5

Distinct and opposing roles for the phosphatidylinositol 3-OH kinase catalytic subunits p110α and p110β in the regulation of insulin secretion from rodent and human beta cells.

Kolic J, Spigelman AF, Plummer G, Leung E, Hajmrle C, Kin T, Shapiro AM, Manning Fox JE, MacDonald PE. Kolic J, et al. Among authors: spigelman af. Diabetologia. 2013 Jun;56(6):1339-49. doi: 10.1007/s00125-013-2882-4. Epub 2013 Apr 9. Diabetologia. 2013. PMID: 23568272

6

SUMO1 enhances cAMP-dependent exocytosis and glucagon secretion from pancreatic α-cells.

Dai XQ, Spigelman AF, Khan S, Braun M, Manning Fox JE, MacDonald PE. Dai XQ, et al. Among authors: spigelman af. J Physiol. 2014 Sep 1;592(17):3715-26. doi: 10.1113/jphysiol.2014.274084. Epub 2014 Jun 6. J Physiol. 2014. PMID: 24907310 Free PMC article.

7

SUMOylation protects against IL-1β-induced apoptosis in INS-1 832/13 cells and human islets.

Hajmrle C, Ferdaoussi M, Plummer G, Spigelman AF, Lai K, Manning Fox JE, MacDonald PE. Hajmrle C, et al. Among authors: spigelman af. Am J Physiol Endocrinol Metab. 2014 Oct 15;307(8):E664-73. doi: 10.1152/ajpendo.00168.2014. Epub 2014 Aug 19. Am J Physiol Endocrinol Metab. 2014. PMID: 25139051 Free PMC article.

8

Insulin secretion induced by glucose-dependent insulinotropic polypeptide requires phosphatidylinositol 3-kinase γ in rodent and human β-cells.

Kolic J, Spigelman AF, Smith AM, Manning Fox JE, MacDonald PE. Kolic J, et al. Among authors: spigelman af. J Biol Chem. 2014 Nov 14;289(46):32109-32120. doi: 10.1074/jbc.M114.577510. Epub 2014 Oct 6. J Biol Chem. 2014. PMID: 25288806 Free PMC article.

9

Research-Focused Isolation of Human Islets From Donors With and Without Diabetes at the Alberta Diabetes Institute IsletCore.

Lyon J, Manning Fox JE, Spigelman AF, Kim R, Smith N, O'Gorman D, Kin T, Shapiro AM, Rajotte RV, MacDonald PE. Lyon J, et al. Among authors: spigelman af. Endocrinology. 2016 Feb;157(2):560-9. doi: 10.1210/en.2015-1562. Epub 2015 Dec 11. Endocrinology. 2016. PMID: 26653569

10

PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets.

Kolic J, Manning Fox JE, Chepurny OG, Spigelman AF, Ferdaoussi M, Schwede F, Holz GG, MacDonald PE. Kolic J, et al. Among authors: spigelman af. Mol Metab. 2016 May 11;5(7):459-471. doi: 10.1016/j.molmet.2016.05.003. eCollection 2016 Jul. Mol Metab. 2016. PMID: 27408772 Free PMC article.

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